{"doi":"10.17615/2k9w-f583","title":"Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues","abstract":"Magnetic nanoparticles (MNPs) are increasingly important in magnetic resonance and biomedical optical imaging. We describe a method for imaging MNPs by detecting nanoscale displacements using a phaseresolved spectral-domain optical coherence tomography (OCT) system. Biological tissues and phantoms are exposed to ∼800 G magnetic fields modulated at 56 and 100 Hz to mechanically actuate embedded iron oxide MNPs (∼20 nm diameter). Sensitivity to 27 μg/g (∼2 nM) MNPs within tissue phantoms is achieved by filtering paramagnetic from diamagnetic vibrations. We demonstrate biological feasibility by imaging topically applied MNPs during their diffusion into an excised rat tumor over a 2 hour time period.","journal":"UNC Libraries","year":2023,"id":408684,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9646,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":530625,"name":"Amy L. Oldenburg","orcid":"0000-0002-2642-8350","position":1,"is_corresponding":false},{"id":366688,"name":"Stephen A. Boppart","orcid":"0000-0002-9386-5630","position":2,"is_corresponding":false},{"id":1188327,"name":"Stephanie A. Rinne","orcid":null,"position":3,"is_corresponding":false},{"id":1157025,"name":"Vasilica Crecea","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:21:18.414003Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}