{"doi":"10.17615/2g2x-cj40","title":"Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: Pooled analysis in five studies within the Ovarian Cancer Association Consortium","abstract":"The association of invasive ovarian carcinoma risk with the functional polymorphism rs2228570 (aka rs10735810; FokI polymorphism) in the vitamin D receptor (VDR) gene was examined in 1820 white non-Hispanic cases and 3479 controls in a pooled analysis of five population-based case-control studies within the Ovarian Cancer Association Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. Carriers of the rare T allele were at increased risk of ovarian carcinoma compared to women with the CC genotype in all studies combined; each copy of the T allele was associated with a modest 9% increased risk (OR=1.09; 95% CI:1.01–1.19; p=0.04). No significant heterogeneity among studies was observed (p=0.37) and, after excluding the dataset from the Hawaii study, the risk association for rs2228570 among replication studies was unchanged (OR=1.09; 95% CI: 1.00–1.19; p=0.06). A stronger association of rs2228570 with risk was observed among younger women (aged < 50 years versus 50 years or older) (p=0.04). In all studies combined, the increased risk per copy of the T allele among younger women was 24% (OR=1.24; 95% CI: 1.04–1.47; p=0.02). This association remained statistically significant after excluding the Hawaii data (OR= 1.20; 95% CI: 1.01–1.43; p=0.04). No heterogeneity of the association was observed by stage (p= 0.46), tumor histology (p=0.98), or time between diagnosis and interview (p=0.94). This pooled analysis provides further evidence that the VDR rs2228570 polymorphism might influence ovarian cancer susceptibility.","journal":"UNC Libraries","year":2020,"id":140763,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9227,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":33597,"name":"Susan J. Ramus","orcid":"0000-0003-0005-7798","position":1,"is_corresponding":false},{"id":33584,"name":"Usha Menon","orcid":"0000-0003-3708-1732","position":2,"is_corresponding":false},{"id":50143,"name":"Aleksandra Gentry-Maharaj","orcid":"0000-0001-7270-9762","position":3,"is_corresponding":false},{"id":33589,"name":"Simon A. Gayther","orcid":"0000-0001-7937-5443","position":4,"is_corresponding":false},{"id":254471,"name":"Estrid Høgdall","orcid":"0000-0003-4689-5658","position":5,"is_corresponding":false},{"id":311543,"name":"Alice S. Whittemore","orcid":"0000-0003-1985-9926","position":6,"is_corresponding":false},{"id":454003,"name":"Galina Lurie","orcid":null,"position":7,"is_corresponding":false},{"id":33548,"name":"Honglin Song","orcid":"0000-0001-5076-7371","position":8,"is_corresponding":false},{"id":453999,"name":"Rachel T. Palmieri","orcid":null,"position":9,"is_corresponding":false},{"id":33585,"name":"Marc T. Goodman","orcid":"0000-0002-4839-3021","position":10,"is_corresponding":false},{"id":33566,"name":"Michael E. Carney","orcid":"0000-0002-5497-405X","position":11,"is_corresponding":false},{"id":254470,"name":"Susanne K. Kjær","orcid":"0000-0002-8347-1398","position":12,"is_corresponding":false},{"id":11264,"name":"Lynne R. Wilkens","orcid":"0000-0001-8408-4536","position":13,"is_corresponding":false},{"id":33596,"name":"Paul D.P. Pharoah","orcid":"0000-0001-8494-732X","position":14,"is_corresponding":false},{"id":311540,"name":"Valerie McGuire","orcid":"0000-0002-9142-2086","position":15,"is_corresponding":false},{"id":33565,"name":"Pamela J. Thompson","orcid":null,"position":16,"is_corresponding":false},{"id":532378,"name":"Richard A. DiCioccio","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:20.701143Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}