{"doi":"10.17615/2f1y-xd68","title":"Multi‐institutional experience with COVID‐19 convalescent plasma in children","abstract":"BACKGROUND AND OBJECTIVES: Convalescent COVID-19 plasma (CCP) was developed and used worldwide as a treatment option by supplying passive immunity. Adult studies suggest administering high-titer CCP early in the disease course of patients who are expected to be antibody-negative; however, pediatric experience is limited. We created a multi-institutional registry to characterize pediatric patients (<18 years) who received CCP and to assess the safety of this intervention. METHODS: A REDCap survey was distributed. The registry collected de-identified data including demographic information (age, gender, and underlying conditions), COVID-19 disease features and concurrent treatments, CCP transfusion and safety events, and therapy response. RESULTS: Ninety-five children received CCP: 90 inpatients and 5 outpatients, with a median age of 10.2 years (range 0-17.9). They were predominantly Latino/Hispanic and White. The most frequent underlying medical conditions were chronic respiratory disease, immunosuppression, obesity, and genetic syndromes. CCP was primarily given as a treatment (95%) rather than prophylaxis (5%). Median total plasma dose administered and transfusion rates were 5.0 ml/kg and 2.6 ml/kg/h, respectively. The transfusions were well-tolerated, with 3 in 115 transfusions reporting mild reactions. No serious adverse events were reported. Severity scores decreased significantly 7 days after CCP transfusion or at discharge. Eighty-five patients (94.4%) survived to hospital discharge. All five outpatients survived to 60 days. CONCLUSIONS: CCP was found to be safe and well-tolerated in children. CCP was frequently given concurrently with other COVID-19-directed treatments with improvement in clinical severity scores ≥7 days after CCP, but efficacy could not be evaluated in this study.","journal":"UNC Libraries","year":2025,"id":577682,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":758890,"name":"Michele Loi","orcid":"0000-0002-6090-6336","position":1,"is_corresponding":false},{"id":449235,"name":"Zachary Willis","orcid":"0000-0002-6372-5274","position":2,"is_corresponding":false},{"id":506158,"name":"Oren Gordon","orcid":"0000-0002-3159-8426","position":3,"is_corresponding":false},{"id":1136472,"name":"Daniel K. Noland","orcid":null,"position":4,"is_corresponding":false},{"id":342565,"name":"Antonio Arrieta","orcid":"0000-0001-9281-8915","position":5,"is_corresponding":false},{"id":1136474,"name":"Elise Zivick","orcid":null,"position":6,"is_corresponding":false},{"id":59344,"name":"Jeffrey R. Donowitz","orcid":"0000-0003-4816-4728","position":7,"is_corresponding":false},{"id":664688,"name":"Emily R. Levy","orcid":"0000-0001-8447-7663","position":8,"is_corresponding":false},{"id":758891,"name":"Kyle Annen","orcid":"0000-0002-7192-5057","position":9,"is_corresponding":false},{"id":1136473,"name":"Noelle Drapeau","orcid":null,"position":10,"is_corresponding":false},{"id":94486,"name":"Meghan Delaney","orcid":"0000-0003-1089-5787","position":11,"is_corresponding":false},{"id":1105897,"name":"Cyril Jacquot","orcid":"0000-0003-1281-0644","position":12,"is_corresponding":false},{"id":1136040,"name":"Stephanie Osborne","orcid":"0000-0001-7050-6275","position":13,"is_corresponding":false},{"id":1136041,"name":"Satyam Arora","orcid":"0000-0002-9048-5624","position":14,"is_corresponding":false},{"id":274832,"name":"Casey A. Rimland","orcid":"0000-0002-5187-6921","position":15,"is_corresponding":false},{"id":241543,"name":"Sanjay K. Jain","orcid":"0000-0001-9620-7070","position":16,"is_corresponding":false},{"id":91687,"name":"Monica I. Ardura","orcid":"0000-0002-2853-2581","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:58:16.148027Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}