{"doi":"10.17615/2a96-q437","title":"Human Immunodeficiency Virus Is Associated with Elevated FibroScan-Aspartate Aminotransferase (FAST) Score","abstract":"Background: Whether human immunodeficiency virus (HIV) infection is associated with the development of nonalcoholic steatohepatitis (NASH) remains unclear. The FibroScan-aspartate aminotransferase (FAST) score was developed to identify patients who have histologic NASH with high nonalcoholic fatty liver disease activity score (NAS ≥4) and significant liver fibrosis (≥F2), which has been associated with higher risk of end-stage liver disease. We examined whether HIV infection is associated with elevated FAST score in a large United States (US) cohort. Methods: Vibration-controlled transient elastography was performed in 1309 women without history of chronic viral hepatitis enrolled from 10 US sites: 928 women with HIV (WWH) and 381 women without HIV (WWOH). We used multivariable logistic regression to evaluate associations of HIV, demographic, lifestyle, and metabolic factors with an elevated (>0.35) FAST score. Results: Median age of WWH and WWOH was 51 years and 48 years, respectively. Most (90%) WWH were on antiretroviral therapy and 72% had undetectable HIV RNA. Prevalence of elevated FAST score was higher among WWH compared to WWOH (6.3% vs 1.8%, respectively; P =. 001). On multivariable analysis, HIV infection was associated with 3.7-fold higher odds of elevated FAST score (P =. 002), and greater waist circumference (per 10 cm) was associated with 1.7-fold higher odds (P <. 001). In analysis limited to WWH, undetectable HIV RNA and current protease inhibitor use were independently associated with lower odds of elevated FAST score. Conclusions: Our findings suggest that HIV is an independent risk factor for NASH with significant activity and fibrosis. Studies validating FAST score in persons with HIV are warranted.","journal":"UNC Libraries","year":2023,"id":415809,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9679,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":597010,"name":"M. Fischl","orcid":null,"position":1,"is_corresponding":false},{"id":1185148,"name":"M. Plankey","orcid":null,"position":2,"is_corresponding":false},{"id":425717,"name":"Mark H. Kuniholm","orcid":"0000-0002-0173-9806","position":3,"is_corresponding":false},{"id":591356,"name":"A.A. Adimora","orcid":null,"position":4,"is_corresponding":false},{"id":1198276,"name":"A.L. French","orcid":null,"position":5,"is_corresponding":false},{"id":591352,"name":"P.C. Tien","orcid":null,"position":6,"is_corresponding":false},{"id":1198237,"name":"E.T. Golub","orcid":null,"position":7,"is_corresponding":false},{"id":315360,"name":"Jennifer C. Price","orcid":"0000-0002-3825-5696","position":8,"is_corresponding":false},{"id":597009,"name":"D. Konkle-Parker","orcid":null,"position":9,"is_corresponding":false},{"id":1197924,"name":"Yanmin Ma","orcid":"0000-0002-9477-2890","position":10,"is_corresponding":false},{"id":382868,"name":"Howard Minkoff","orcid":"0000-0002-7800-7195","position":11,"is_corresponding":false},{"id":597006,"name":"I. Ofotokun","orcid":null,"position":12,"is_corresponding":false},{"id":1159138,"name":"A. Sharma","orcid":"0009-0001-4508-3984","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:22:15.958504Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}