{"doi":"10.17615/1w0s-td96","title":"High Payload Dual Therapeutic-Imaging Nanocarriers for Triggered Tumor Delivery","abstract":"The in vitro and in vivo characterization of an optimized formulation of nanoparticles (NPs) loaded with a high content of dexamethasone palmitate (DEX-P), a chemotherapeutic adjuvant that decreases interstitial fluid pressure in tumors, and 111In, a signaling agent, is described. These NPs are uniform in size and composition. Single photon emission computed tomography imaging demonstrates significant tumor uptake of 111In-labeled DEX-P NPs in tumor-bearing mice. As with many nanoparticle-based drug delivery systems, significant liver accumulation is observed. Assessment of liver histology and blood tests show no apparent hepatic or renal toxicity of the DEX-P NPs. Conversion of DEX-P to DEX occurs when DEX-P NPs are incubated with mouse plasma, human tumor homogenate and ascites from tumor bearing mice, but not with human plasma. This conversion is slower in plasma from Es1e(−/−)/SCID mice, a potential alternative animal model that better mimics humans; however, plasma from these mice are not completely devoid of esterase activity. The difference between blood and tumor esterase activity in humans facilitates the delivery of DEX-P NPs to tumors and the release of dexamethasone by an esterase trigger.","journal":"UNC Libraries","year":2020,"id":136567,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9473,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":595700,"name":"Xiuling Lu","orcid":null,"position":1,"is_corresponding":false},{"id":548646,"name":"Markos Leggas","orcid":"0000-0003-4314-4533","position":2,"is_corresponding":false},{"id":594996,"name":"Jin‐Ki Kim","orcid":"0000-0002-1944-1231","position":3,"is_corresponding":false},{"id":533445,"name":"Jingxin Nie","orcid":"0000-0002-0237-2559","position":4,"is_corresponding":false},{"id":546743,"name":"Hong Yuan","orcid":"0000-0001-9685-2440","position":5,"is_corresponding":false},{"id":547095,"name":"Michael Jay","orcid":"0000-0003-4114-9007","position":6,"is_corresponding":false},{"id":595701,"name":"John S. Rinehart","orcid":null,"position":7,"is_corresponding":false},{"id":595702,"name":"Yu-Tsai Yang","orcid":null,"position":8,"is_corresponding":false},{"id":464228,"name":"Philip M. Potter","orcid":"0000-0001-8922-8535","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:48.793683Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}