{"doi":"10.17615/1hvb-0638","title":"Anthropometric and sociodemographic variables, but not preconception or prenatal maternal nutrition supplementation, predict neurodevelopment in offspring of the ‘Women First’ trial","abstract":"Multiple factors influence infant and child neurodevelopment in low resource settings. In offspring of participants in the preconception maternal nutrition trial, Women First&nbsp;(WF), we examined the impact of providing a preconception (Arm 1) or prenatal (Arm 2) nutrient supplement (compared to controls, Arm 3) on neurodevelopmental outcomes at 24 months; predictors of neurodevelopment scores; and associations of infant anthropometrics with neurodevelopmental scores. Follow-up visits for anthropometry were conducted at 6-, 12-, 18-&nbsp;and 24-month&nbsp;of age. At 24-months, in a randomized subset,&nbsp;the Bayley Scales of Infant Development, 3rd&nbsp;edition (BSID-III), including cognitive, motor&nbsp;and social-emotional subscales,&nbsp;and the Family Care Indicators (FCI) questionnaire, assessing family and home environment, were completed. Multiple covariates (intervention arm, site, maternal sociodemographic characteristics, FCI subscales, birthweight&nbsp;and 6-24 months'&nbsp;change in anthropometry z-scores, (e.g., &Delta;LAZ<sub>6-2</sub> <sub>4</sub>) were evaluated by linear regression to predict BSID-III outcomes and to assess associations of anthropometric changes with BSID-III scores. The analysis consisted of 1386 infants (n&thinsp;=&thinsp;441, 486, 459 for Arms 1, 2&nbsp;and 3, respectively). None of the domain-specific BSID-III subscale scores differed by maternal intervention arm. Four covariates significantly predicted (p&thinsp;&le;&thinsp;0.01) all 3 BSID-III subscales: secondary maternal education, &Delta;LAZ<sub>6</sub> <sub>-</sub> <sub>24</sub>, birthweight &gt;2500&thinsp;g, and FCI play materials. Linear growth was associated with all domains of neurodevelopment. The results underscore the multi-dimensional aspects of child development represented by the nurturing care framework, including prenatal maternal nutrition, post-natal growth, maternal education for responsive caregiving&nbsp;and opportunities for early learning.","journal":"UNC Libraries","year":2025,"id":581140,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":605904,"name":"Melissa Bauserman","orcid":"0000-0002-4992-9895","position":1,"is_corresponding":false},{"id":613287,"name":"Fred J. Biasini","orcid":null,"position":2,"is_corresponding":false},{"id":609231,"name":"Michael Hambidge","orcid":null,"position":3,"is_corresponding":false},{"id":334069,"name":"Shivaprasad S. Goudar","orcid":"0000-0002-8680-7053","position":4,"is_corresponding":false},{"id":299389,"name":"Nancy F. Krebs","orcid":"0000-0001-5652-7547","position":5,"is_corresponding":false},{"id":733790,"name":"Sumera Aziz Ali","orcid":"0000-0001-8996-7995","position":6,"is_corresponding":false},{"id":699616,"name":"Jamie Westcott","orcid":"0000-0002-0549-3145","position":7,"is_corresponding":false},{"id":270631,"name":"Antoinette Tshefu","orcid":"0000-0001-7657-6901","position":8,"is_corresponding":false},{"id":902328,"name":"Jennifer F Kemp","orcid":null,"position":9,"is_corresponding":false},{"id":262902,"name":"Robert L. Goldenberg","orcid":"0000-0002-1283-8340","position":10,"is_corresponding":false},{"id":764354,"name":"Sangappa Dhaded","orcid":"0000-0001-9575-5251","position":11,"is_corresponding":false},{"id":230768,"name":"Abhik Das","orcid":"0000-0003-2722-0479","position":12,"is_corresponding":false},{"id":334067,"name":"Adrien Lokangaka","orcid":"0000-0002-8609-5877","position":13,"is_corresponding":false},{"id":1286903,"name":"Ana Garcés","orcid":"0000-0002-0878-5274","position":14,"is_corresponding":false},{"id":1067492,"name":"Stephanie Waldrop","orcid":"0000-0001-7654-2816","position":15,"is_corresponding":false},{"id":335596,"name":"Marion Koso‐Thomas","orcid":null,"position":16,"is_corresponding":false},{"id":334068,"name":"Sarah Saleem","orcid":"0000-0002-6797-8631","position":17,"is_corresponding":false},{"id":715900,"name":"Lester Figueroa","orcid":"0000-0003-1732-0361","position":18,"is_corresponding":false},{"id":334070,"name":"Richard J. Derman","orcid":"0000-0003-1148-1594","position":19,"is_corresponding":false},{"id":1287358,"name":"The Women First Preconception Nutrition Trial Study Group","orcid":null,"position":20,"is_corresponding":false},{"id":861931,"name":"Dhuly Chowdhury","orcid":"0000-0002-0590-8806","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:58:47.357782Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}