{"doi":"10.17615/1e5f-cc93","title":"α-Synuclein, a chemoattractant, directs microglial migration via H 2 O 2 -dependent Lyn phosphorylation","abstract":"α-Synuclein (α-syn) aggregates released from neurons activate microglia, leading to chronic neuroinflammation that causes damage to neurons in brains with synucleinopathies, such as Parkinson’s disease (PD). However, little is known about the mechanism by which α-syn affects microglial activity, especially motility, and why microglia migrate toward the injured neurons and preferentially accumulate along with α-syn aggregates in the affected areas, e.g., in the substantia nigra of PD brains. Here we show that neuron-derived α-syn aggregates are chemoattractants that direct microglial migration by acting on NADPH oxidase and several specific downstream proteins. Blocking the targets involved in α-syn–mediated microglial directional migration may represent a therapeutic strategy to protect against progressive neuronal loss in PD and related synucleinopathies.","journal":"UNC Libraries","year":2020,"id":113495,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":535373,"name":"Chun‐Hsien Chu","orcid":"0000-0003-2934-2584","position":1,"is_corresponding":false},{"id":279662,"name":"Belinda Wilson","orcid":null,"position":2,"is_corresponding":false},{"id":535374,"name":"Shijun Wang","orcid":"0000-0001-7290-412X","position":3,"is_corresponding":false},{"id":255753,"name":"Jing Zhang","orcid":"0000-0001-7525-2075","position":4,"is_corresponding":false},{"id":535375,"name":"Yifei Wang","orcid":"0000-0002-9918-2865","position":5,"is_corresponding":false},{"id":535987,"name":"Carmen Ginghină","orcid":null,"position":6,"is_corresponding":false},{"id":33020,"name":"Tessandra Stewart","orcid":null,"position":7,"is_corresponding":false},{"id":535376,"name":"Hui Nie","orcid":"0000-0002-0447-8138","position":8,"is_corresponding":false},{"id":276867,"name":"Jau‐Shyong Hong","orcid":"0000-0002-3056-8401","position":9,"is_corresponding":false},{"id":535986,"name":"Mingri Guo","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:21.458038Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}