{"doi":"10.17615/18v5-mv62","title":"Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy","abstract":"Despite antiretroviral therapy, proviral latency of human immunodeficiency virus type 1 (HIV-1) remains a principal obstacle to curing the infection [1]. Inducing the expression of latent genomes within resting CD4+ T cells is the primary strategy to clear this reservoir [2]. While histone deacetylase (HDAC) inhibitors such as suberoylanilide hydroxamic acid (SAHA or vorinostat, VOR) can disrupt HIV-1 latency in vitro [3–5], the utility of this approach has never been directly proven in a translational clinical study of HIV-infected patients.Therefore we isolated the circulating resting CD4+ T cells of patients in whom viremia was fully suppressed by antiretroviral therapy (ART), and directly studied the effect of VOR in this latent reservoir. In each of eight patients studied, a single dose of VOR increased both biomarkers of cellular acetylation, and simultaneously induced an increase in HIV RNA expression in resting CD4+ cells (mean increase 4.8-fold). This is the first demonstration that a molecular mechanism known to enforce HIV latency can be therapeutically targeted in man, provides proof-of-concept for HDAC inhibitors as a new therapeutic class, and defines a precise approach to test novel strategies to directly attack and eradicate latent HIV infection.","journal":"UNC Libraries","year":2020,"id":98224,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":485724,"name":"A. D. Kashuba","orcid":null,"position":1,"is_corresponding":false},{"id":485725,"name":"A. L. Liberty","orcid":null,"position":2,"is_corresponding":false},{"id":485726,"name":"R. J. Bosch","orcid":null,"position":3,"is_corresponding":false},{"id":485727,"name":"D. M. Margolis","orcid":null,"position":4,"is_corresponding":false},{"id":485728,"name":"A. M. Crooks","orcid":null,"position":5,"is_corresponding":false},{"id":485729,"name":"J. J. Eron","orcid":null,"position":6,"is_corresponding":false},{"id":485730,"name":"M. C. Strain","orcid":null,"position":7,"is_corresponding":false},{"id":485731,"name":"Sarita Choudhary","orcid":null,"position":8,"is_corresponding":false},{"id":485732,"name":"D. D. Richman","orcid":null,"position":9,"is_corresponding":false},{"id":485733,"name":"N. M. Archin","orcid":null,"position":10,"is_corresponding":false},{"id":437137,"name":"M. G. Hudgens","orcid":null,"position":11,"is_corresponding":false},{"id":485734,"name":"E. M. Anderson","orcid":null,"position":12,"is_corresponding":false},{"id":485735,"name":"J. D. Kuruc","orcid":null,"position":13,"is_corresponding":false},{"id":485736,"name":"J. M. Coffin","orcid":null,"position":14,"is_corresponding":false},{"id":485737,"name":"D. J. Hazuda","orcid":null,"position":15,"is_corresponding":false},{"id":485738,"name":"D. C. Parker","orcid":null,"position":16,"is_corresponding":false},{"id":485723,"name":"M. F. Kearney","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T22:36:34.157932Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}