{"doi":"10.17615/1769-bm56","title":"A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation","abstract":"Aberrant splicing is frequently found in cancer, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo–YAP signalling, a key pathway that regulates cell proliferation and organ size, is under control of a splicing switch. We show that TEAD4, the transcription factor that mediates Hippo–YAP signalling, undergoes alternative splicing facilitated by the tumour suppressor RBM4, producing a truncated isoform, TEAD4-S, which lacks an N-terminal DNA-binding domain, but maintains YAP interaction domain. TEAD4-S is located in both the nucleus and cytoplasm, acting as a dominant negative isoform to YAP activity. Consistently, TEAD4-S is reduced in cancer cells, and its re-expression suppresses cancer cell proliferation and migration, inhibiting tumour growth in xenograft mouse models. Furthermore, TEAD4-S is reduced in human cancers, and patients with elevated TEAD4-S levels have improved survival. Altogether, these data reveal a splicing switch that serves to fine tune the Hippo–YAP pathway.","journal":"UNC Libraries","year":2020,"id":115214,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":45531,"name":"Yang Wang","orcid":"0000-0001-9385-7393","position":1,"is_corresponding":false},{"id":525124,"name":"Haili Qian","orcid":"0000-0003-0652-4801","position":2,"is_corresponding":false},{"id":525127,"name":"Quentin Liu","orcid":"0000-0002-0999-9805","position":3,"is_corresponding":false},{"id":540819,"name":"Huanhuan Wei","orcid":"0000-0002-6481-5407","position":4,"is_corresponding":false},{"id":287635,"name":"Zefeng Wang","orcid":"0000-0002-6605-3637","position":5,"is_corresponding":false},{"id":540820,"name":"Wenjing Zhang","orcid":"0009-0004-2459-5587","position":6,"is_corresponding":false},{"id":540821,"name":"Xiaojuan Fan","orcid":"0009-0001-9453-9386","position":7,"is_corresponding":false},{"id":540822,"name":"Jing Yu","orcid":"0000-0002-8694-8948","position":8,"is_corresponding":false},{"id":525126,"name":"Yi‐Hsuan Tsai","orcid":"0000-0003-2107-4300","position":9,"is_corresponding":false},{"id":540823,"name":"Songshu Meng","orcid":"0000-0001-9432-2243","position":10,"is_corresponding":false},{"id":541433,"name":"Yangfan Qi","orcid":null,"position":11,"is_corresponding":false},{"id":540824,"name":"Wei Han","orcid":"0000-0001-6038-7911","position":12,"is_corresponding":false},{"id":541432,"name":"Jinyao Zhao","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:36.820928Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}