{"doi":"10.17615/11x8-k278","title":"Solithromycin Pharmacokinetics in Plasma and Dried Blood Spots and Safety in Adolescents","abstract":"ABSTRACT We assessed the pharmacokinetics and safety of solithromycin, a fluoroketolide antibiotic, in a phase 1, open-label, multicenter study of 13 adolescents with suspected or confirmed bacterial infections. On days 3 to 5, the mean (standard deviation) maximum plasma concentration and area under the concentration versus time curve from 0 to 24 h were 0.74 μg/ml (0.61 μg/ml) and 9.28 μg · h/ml (6.30 μg · h/ml), respectively. The exposure and safety in this small cohort of adolescents were comparable to those for adults. (This study has been registered at ClinicalTrials.gov under registration no. NCT01966055.)","journal":"UNC Libraries","year":2020,"id":136013,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9482,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":594350,"name":"Jr. Kara Keedy","orcid":null,"position":1,"is_corresponding":false},{"id":594351,"name":"Leena Bhattacharya-Mithal","orcid":null,"position":2,"is_corresponding":false},{"id":348339,"name":"John S. Bradley","orcid":"0000-0002-3835-5064","position":3,"is_corresponding":false},{"id":333631,"name":"Michael Cohen‐Wolkowiez","orcid":"0000-0002-2458-2266","position":4,"is_corresponding":false},{"id":594352,"name":"Theresa Jasion","orcid":null,"position":5,"is_corresponding":false},{"id":342566,"name":"Laura P. James","orcid":"0000-0002-4266-3924","position":6,"is_corresponding":false},{"id":326442,"name":"Daniel K. Benjamin","orcid":"0000-0002-0764-8585","position":7,"is_corresponding":false},{"id":333627,"name":"Christoph P. Hornik","orcid":"0000-0001-7056-8759","position":8,"is_corresponding":false},{"id":333630,"name":"P. Brian Smith","orcid":"0000-0002-9330-3048","position":9,"is_corresponding":false},{"id":593606,"name":"Natalie Neu","orcid":"0000-0001-5462-2938","position":10,"is_corresponding":false},{"id":96349,"name":"Prabhavathi Fernandes","orcid":"0000-0003-1349-8840","position":11,"is_corresponding":false},{"id":342569,"name":"Amira Al‐Uzri","orcid":"0000-0001-6532-7117","position":12,"is_corresponding":false},{"id":594353,"name":"Debra L. Palazzi","orcid":null,"position":13,"is_corresponding":false},{"id":326445,"name":"Daniel González","orcid":"0000-0001-5522-5686","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:35.237665Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}