{"doi":"10.17615/0xj9-x962","title":"Vitamin E intake from natural sources and head and neck cancer risk: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium","abstract":"BACKGROUND: Evidence for the possible effect of vitamin E on head and neck cancers (HNCs) is limited. METHODS: We used individual-level pooled data from 10 case-control studies (5959 cases and 12 248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium to assess the association between vitamin E intake from natural sources and cancer of the oral cavity/pharynx and larynx. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models applied to quintile categories of non-alcohol energy-adjusted vitamin E intake. RESULTS: Intake of vitamin E was inversely related to oral/pharyngeal cancer (OR for the fifth vs the first quintile category=0.59, 95% CI: 0.49-0.71; P for trend <0.001) and to laryngeal cancer (OR=0.67, 95% CI: 0.54-0.83, P for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral/pharyngeal cancer. Inverse associations were generally observed for the anatomical subsites of oral and pharyngeal cancer and within covariate strata for both sites. CONCLUSION: Our findings suggest that greater vitamin E intake from foods may lower HNC risk, although we were not able to explain the heterogeneity observed across studies or rule out certain sources of bias.","journal":null,"year":2020,"id":118019,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":5906,"name":"Carlo La Vecchia","orcid":"0000-0003-1441-897X","position":1,"is_corresponding":false},{"id":549749,"name":"M. Ferraroni","orcid":null,"position":2,"is_corresponding":false},{"id":476140,"name":"K. Kelsey","orcid":null,"position":3,"is_corresponding":false},{"id":265964,"name":"Valeria Edefonti","orcid":"0000-0002-1995-1477","position":4,"is_corresponding":false},{"id":549750,"name":"G. P. Yu","orcid":null,"position":5,"is_corresponding":false},{"id":549751,"name":"A.F. Olshan","orcid":null,"position":6,"is_corresponding":false},{"id":549752,"name":"M. Parpinel","orcid":null,"position":7,"is_corresponding":false},{"id":64909,"name":"M. McClean","orcid":null,"position":8,"is_corresponding":false},{"id":549753,"name":"K. Moysich","orcid":null,"position":9,"is_corresponding":false},{"id":476130,"name":"F. Levi","orcid":null,"position":10,"is_corresponding":false},{"id":265936,"name":"Diego Serraino","orcid":"0000-0003-0565-8920","position":11,"is_corresponding":false},{"id":476126,"name":"H. Morgenstern","orcid":null,"position":12,"is_corresponding":false},{"id":31513,"name":"Keitaro Matsuo","orcid":"0000-0003-1761-6314","position":13,"is_corresponding":false},{"id":549754,"name":"Y. C. A Lee","orcid":null,"position":14,"is_corresponding":false},{"id":265958,"name":"Zuo‐Feng Zhang","orcid":"0000-0002-4669-3995","position":15,"is_corresponding":false},{"id":265963,"name":"Paolo Boffetta","orcid":"0000-0002-3811-2791","position":16,"is_corresponding":false},{"id":549755,"name":"M. Hashibe","orcid":null,"position":17,"is_corresponding":false},{"id":269019,"name":"Stimson Schantz","orcid":null,"position":18,"is_corresponding":false},{"id":549756,"name":"F. Turati","orcid":null,"position":19,"is_corresponding":false},{"id":549757,"name":"Sophie C. Chuang","orcid":null,"position":20,"is_corresponding":false},{"id":265955,"name":"José P. Zevallos","orcid":"0000-0002-9111-6767","position":21,"is_corresponding":false},{"id":549758,"name":"D. M. 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