{"doi":"10.17615/08se-ge77","title":"Patterns and Predictors of Cognitive Function Among Virally Suppressed Women With HIV","abstract":"Cognitive impairment remains frequent and heterogeneous in presentation and severity among virally suppressed (VS) women with HIV (WWH). We identified cognitive profiles among 929 VS-WWH and 717 HIV-uninfected women from 11 Women's Interagency HIV Study sites at their first neuropsychological (NP) test battery completion comprised of: Hopkins Verbal Learning Test-Revised, Trail Making, Symbol Digit Modalities, Grooved Pegboard, Stroop, Letter/Animal Fluency, and Letter-Number Sequencing. Using 17 NP performance metrics (T-scores), we used Kohonen self-organizing maps to identify patterns of high-dimensional data by mapping participants to similar nodes based on T-scores and clustering those nodes. Among VS-WWH, nine clusters were identified (entropy = 0.990) with four having average T-scores ≥45 for all metrics and thus combined into an “unimpaired” profile (n = 311). Impaired profiles consisted of weaknesses in: (1) sequencing (Profile-1; n = 129), (2) speed (Profile-2; n = 144), (3) learning + recognition (Profile-3; n = 137), (4) learning + memory (Profile-4; n = 86), and (5) learning + processing speed + attention + executive function (Profile-5; n = 122). Sociodemographic, behavioral, and clinical variables differentiated profile membership using Random Forest models. The top 10 variables distinguishing the combined impaired vs. unimpaired profiles were: clinic site, age, education, race, illicit substance use, current and nadir CD4 count, duration of effective antiretrovirals, and protease inhibitor use. Additional variables differentiating each impaired from unimpaired profile included: depression, stress-symptoms, income (Profile-1); depression, employment (Profile 2); depression, integrase inhibitor (INSTI) use (Profile-3); employment, INSTI use, income, atazanavir use, non-ART medications with anticholinergic properties (Profile-4); and marijuana use (Profile-5). Findings highlight consideration of NP profile heterogeneity and potential modifiable factors contributing to impaired profiles.","journal":"UNC Libraries","year":2023,"id":415876,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":419824,"name":"Gayle Springer","orcid":"0000-0003-4583-7325","position":1,"is_corresponding":false},{"id":1156508,"name":"H. Bolivar","orcid":null,"position":2,"is_corresponding":false},{"id":1159605,"name":"R. Dastgheyb","orcid":null,"position":3,"is_corresponding":false},{"id":241632,"name":"Kathryn C. Fitzgerald","orcid":"0000-0003-3137-0322","position":4,"is_corresponding":false},{"id":404728,"name":"Amanda B. Spence","orcid":"0000-0001-9011-8456","position":5,"is_corresponding":false},{"id":269724,"name":"Norman J. Haughey","orcid":"0000-0001-5194-4122","position":6,"is_corresponding":false},{"id":596999,"name":"J. Milam","orcid":null,"position":7,"is_corresponding":false},{"id":104956,"name":"Pauline M. Maki","orcid":"0000-0002-8443-3430","position":8,"is_corresponding":false},{"id":69479,"name":"Dionne W. Williams","orcid":"0000-0001-5029-2628","position":9,"is_corresponding":false},{"id":525526,"name":"Deborah P. Waldrop","orcid":"0000-0001-8325-2147","position":10,"is_corresponding":false},{"id":259565,"name":"Leah H. Rubin","orcid":"0000-0003-2749-6328","position":11,"is_corresponding":false},{"id":1198321,"name":"Analena Buchholz","orcid":null,"position":12,"is_corresponding":false},{"id":1198322,"name":"Kerstin Weber","orcid":null,"position":13,"is_corresponding":false},{"id":1159612,"name":"D.R. Gustafson","orcid":null,"position":14,"is_corresponding":false},{"id":603253,"name":"Yinyan Xu","orcid":"0000-0001-7960-8278","position":15,"is_corresponding":false},{"id":1198323,"name":"D.E. Vance","orcid":null,"position":16,"is_corresponding":false},{"id":591356,"name":"A.A. Adimora","orcid":null,"position":17,"is_corresponding":false},{"id":591317,"name":"K. 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