{"doi":"10.17615/07fz-zt78","title":"New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk","abstract":"To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.","journal":"Research at the University of Copenhagen (University of Copenhagen)","year":2020,"id":128622,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9317,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":21702,"name":"Stavroula Kanoni","orcid":"0000-0002-1691-9615","position":1,"is_corresponding":false},{"id":579323,"name":"Ghazaleh Fatemifar","orcid":"0000-0002-2321-4963","position":2,"is_corresponding":false},{"id":38852,"name":"Tiina Laatikainen","orcid":"0000-0002-6614-4782","position":3,"is_corresponding":false},{"id":21805,"name":"Cristina Menni","orcid":"0000-0001-9790-0571","position":4,"is_corresponding":false},{"id":21797,"name":"Yingchang Lu","orcid":null,"position":5,"is_corresponding":false},{"id":21684,"name":"Anna A. 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