{"doi":"10.1677/joe.0.1010107","title":"Control of thyroglobulin secretion from the rat thyroid gland","abstract":"<jats:title>ABSTRACT</jats:title>\n                  <jats:p>Serum thyroglobulin (Tg), measured by radioimmunoassay, was high in 6-propylthiouracil (PTU)-treated rats but low in thyroxine (T4)-treated animals compared with euthyroid controls. Thyroid-stimulating hormone (TSH) stimulated Tg release in vitro from enzymatically dispersed normal rat thyroid cells in a dose-dependent manner. Thyroid cells prepared from T4-treated animals behaved similarly to cells from control rats, whereas in vitro basal release of Tg from thyroid cells prepared from PTU-treated animals was high and the response to TSH was lost. Our data confirm the TSH dependency of Tg release in vivo and in vitro and our system provides a means of studying the control of Tg secretion in vitro.</jats:p>\n                  <jats:p>J. Endocr. (1984) 101, 107–111</jats:p>","journal":"Journal of Endocrinology","year":1984,"id":679172,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":204287,"name":"M. C. Sheppard","orcid":null,"position":1,"is_corresponding":false},{"id":1774530,"name":"R. Hoffenberg","orcid":null,"position":2,"is_corresponding":false},{"id":738469,"name":"E. G. Black","orcid":"0000-0001-7252-6827","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Control of thyroglobulin secretion from the rat thyroid gland","abstract":"<jats:title>ABSTRACT</jats:title>\n                  <jats:p>Serum thyroglobulin (Tg), measured by radioimmunoassay, was high in 6-propylthiouracil (PTU)-treated rats but low in thyroxine (T4)-treated animals compared with euthyroid controls. Thyroid-stimulating hormone (TSH) stimulated Tg release in vitro from enzymatically dispersed normal rat thyroid cells in a dose-dependent manner. Thyroid cells prepared from T4-treated animals behaved similarly to cells from control rats, whereas in vitro basal release of Tg from thyroid cells prepared from PTU-treated animals was high and the response to TSH was lost. Our data confirm the TSH dependency of Tg release in vivo and in vitro and our system provides a means of studying the control of Tg secretion in vitro.</jats:p>\n                  <jats:p>J. Endocr. (1984) 101, 107–111</jats:p>","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6707550","pmcid":null,"openalex_id":"https://openalex.org/W2074577918","authors":[],"funders":[],"total_grants":0,"fwci":0.8933,"citation_percentile":0.72495799,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://joe.bioscientifica.com/view/journals/joe/101/1/joe_101_1_017.xml","host_type":"publisher"},{"url":"https://journals.bioscientifica.com/joe/article-pdf/101/1/107/94494/joe_101_1_017.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1677/joe.0.1010107","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6707550","host_type":"repository"}],"fields_of_study":["Thyroid Disorders and Treatments","Ion channel regulation and function","Animals","Dose-Response Relationship, Drug","Female","In Vitro Techniques","Propylthiouracil","Radioimmunoassay","Rats","Rats, Inbred Strains","Thyroglobulin","Thyroid Gland","Thyrotropin","Thyroxine"],"mesh_terms":["Animals","Dose-Response Relationship, Drug","Female","Propylthiouracil","Radioimmunoassay","Rats, Inbred Strains","Thyroglobulin","Thyroid Gland","Thyrotropin","Thyroxine","Rats","In Vitro Techniques"],"keywords":["Propylthiouracil","Internal medicine","Endocrinology","Thyroglobulin","Thyroid","Euthyroid","In vitro","Radioimmunoassay","In vivo","Secretion","Hormone","Chemistry","Basal (medicine)","Medicine","Biology","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T12:24:08.025704Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}