{"doi":"10.1677/joe.0.0940317","title":"Effects of domperidone on the secretion of prolactin from rat anterior pituitary glands","abstract":"<jats:p>The effects of domperidone on prolactin secretion from the anterior pituitary glands of female rats were studied. A perifusion system and radioimmunoassay were used to study secretion; static incubations and incorporation of [<jats:sup>3</jats:sup>H]leucine were used to measure biosynthesis. During perifusion, intact anterior lobes showed a constant rate of prolactin secretion for up to 5 h (after a 90-min preincubation to stabilize the tissue). Incorporation studies revealed an increase in protein synthesis in perifused hemipituitary glands. When glands were treated with 10 n<jats:sc>m</jats:sc>-domperidone, prolactin secretion began to decline after the first hour, reaching a maximum of 40–50% inhibition after a further 90 min. Growth hormone secretion showed no such decline. Inhibition of prolactin secretion continued for up to 2 h after withdrawal of the drug. Treatment with 100 n<jats:sc>m</jats:sc>-dopamine resulted in a more rapid inhibition of secretion, but the effect was reversed on withdrawal of the catecholamine. The prolactin content of perifused hemipituitary glands was measured after treatment with domperidone; the contents of control and treated glands did not differ, but were depleted compared with hemipituitary glands which had not been perifused.</jats:p>","journal":"Journal of Endocrinology","year":1982,"id":42795,"datarank":0.49632413128018327,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.2044376089218862,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.2044376089218862,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":4,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":204304,"name":"M. Wallis","orcid":null,"position":1,"is_corresponding":false},{"id":204303,"name":"A. M. Bentley","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7119643","pmcid":null,"openalex_id":"https://openalex.org/W1966296538","authors":[],"funders":[],"total_grants":0,"fwci":2.1228,"citation_percentile":0.85570537,"influential_citations":0,"citation_trend":[{"year":2021,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://joe.bioscientifica.com/view/journals/joe/94/3/joe_94_3_002.xml","host_type":"publisher"},{"url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/94/3/joe_94_3_002.xml","host_type":"publisher"},{"url":"https://doi.org/10.1677/joe.0.0940317","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7119643","host_type":"repository"}],"fields_of_study":["Hypothalamic control of reproductive hormones","Growth Hormone and Insulin-like Growth Factors","Ovarian function and disorders","Biology","Medicine","Animals","Domperidone","Female","Growth Hormone","In Vitro Techniques","Perfusion","Pituitary Gland, Anterior","Prolactin","Rats","Rats, Inbred Strains"],"mesh_terms":["Animals","Domperidone","Female","Perfusion","Pituitary Gland, Anterior","Prolactin","Rats, Inbred Strains","Growth Hormone","Rats","In Vitro Techniques"],"keywords":["Domperidone","Internal medicine","Endocrinology","Prolactin","Anterior pituitary","Secretion","Prolactin cell","Radioimmunoassay","Dopamine","Pituitary gland","Hypothalamus","Catecholamine","Hormone","Biology","Chemistry","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-14T05:33:50.865228Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}