{"doi":"10.1677/joe.0.0850069","title":"EFFECT OF NEONATAL ADMINISTRATION OF STEROIDS OR GONADECTOMY UPON OESTRADIOL-INDUCED LUTEINIZING HORMONE RELEASE IN RATS OF BOTH SEXES","abstract":"<jats:title>SUMMARY</jats:title>\n        <jats:p>Implantation of oestradiol into adult rats of both sexes induced different patterns of LH secretion depending on the time at which gonadectomy or testosterone injection were performed. Castration 2 h after birth allowed an LH peak to occur daily at 18.00 h, but its amplitude was lower than that of adult gonadectomized female rats treated with oestradiol. Castration 24 h after birth elicited two kinds of response; a circadian discharge of LH lower than that of male rats gonadectomized 2 h after birth or a steady low level of LH. The LH rhythmicity induced by implantation of oestradiol was not seen after castration at 8 weeks of age. Neonatal administration of testosterone to female rats prevented the LH peak induced by oestradiol that was seen in adult ovariectomized rats. Neonatal or adult ovariectomy did not interfere with the rhythmical response of LH after implantation of oestradiol. Thus, it is concluded that sexual differentiation of the hypothalamus is primarily of masculine origin.</jats:p>","journal":"Journal of Endocrinology","year":1980,"id":15173,"datarank":2.5148057284917185,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":1.957769918486072,"self_endowment_contribution":0.5570358100056463,"citer_contribution":1.957769918486072,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":40,"citers_with_citation_signal":36,"citers_with_endowment":36,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":116814,"name":"I. A. BEATTIE","orcid":null,"position":1,"is_corresponding":false},{"id":116815,"name":"M. HERY","orcid":null,"position":2,"is_corresponding":false},{"id":116816,"name":"E. LAPLANTE","orcid":null,"position":3,"is_corresponding":false},{"id":116817,"name":"C. KORDON","orcid":null,"position":4,"is_corresponding":false},{"id":116813,"name":"F. GOGAN","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.713572066704308,"endowment":3.713572066704308,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7391724","pmcid":null,"openalex_id":"https://openalex.org/W2076924632","authors":[],"funders":[],"total_grants":0,"fwci":0.677,"citation_percentile":0.66804979,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2015,"count":2},{"year":2016,"count":4},{"year":2017,"count":2},{"year":2018,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://joe.bioscientifica.com/view/journals/joe/85/1/joe_85_1_009.xml","host_type":"publisher"},{"url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/85/1/joe_85_1_009.xml","host_type":"publisher"},{"url":"https://doi.org/10.1677/joe.0.0850069","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7391724","host_type":"repository"}],"fields_of_study":["Growth Hormone and Insulin-like Growth Factors","Hypothalamic control of reproductive hormones","Regulation of Appetite and Obesity","Biology","Medicine","Animals","Animals, Newborn","Castration","Estradiol","Female","Hypothalamus","Luteinizing Hormone","Male","Rats","Secretory Rate","Testosterone"],"mesh_terms":["Animals","Animals, Newborn","Castration","Estradiol","Female","Hypothalamus","Luteinizing Hormone","Male","Secretory Rate","Testosterone","Rats"],"keywords":["Castration","Internal medicine","Endocrinology","Testosterone (patch)","Ovariectomized rat","Luteinizing hormone","Hypothalamus","Hormone","Medicine","Chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T16:40:25.821260Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}