{"doi":"10.1677/joe.0.0790271","title":"DEPENDENCE OF GLUTAMINE METABOLISM AND AMMONIA SYNTHESIS ON SEX IN RAT KIDNEY SLICES","abstract":"<jats:p>The uptake and metabolism of glutamine, production of ammonia and consumption of O<jats:sub>2</jats:sub> were studied in kidney slices isolated from mature, gonadectomized and newborn male and female rats in the presence of 0·05, 0·5, 2 and 5 m<jats:sc>m</jats:sc>-glutamine. Slices isolated from mature intact female rats showed significantly greater conversion of glutamine into CO<jats:sub>2</jats:sub> and NH<jats:sub>3</jats:sub> without any change in the total uptake of glutamine when compared with all other experimental groups. No difference in O<jats:sub>2</jats:sub> consumption was found between mature male and female animals. Ovariectomy reduced glutamine metabolism, NH<jats:sub>3</jats:sub> production and O<jats:sub>2</jats:sub> consumption without any effect on the total uptake of glutamine. In contrast, castration did not significantly affect glutamine metabolism and production of NH<jats:sub>3</jats:sub> but did reduce O<jats:sub>2</jats:sub> consumption. Newborn (20- to 21-day-old) rats showed no sex-dependent differences in glutamine uptake and metabolism, production of NH<jats:sub>3</jats:sub> and consumption of O<jats:sub>2</jats:sub>, but values for all these parameters were lower in kidney slices from newborn animals than in kidney slices from mature, intact or gonadectomized male and female rats. It is concluded that in female rats, metabolism of glutamine and production of NH<jats:sub>3</jats:sub> may be influenced by ovarian sex hormones.</jats:p>","journal":"Journal of Endocrinology","year":1978,"id":19132,"datarank":0.39228501917367226,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.15086933230855717,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.15086933230855717,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":2,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":130585,"name":"S. SOLOMON","orcid":null,"position":1,"is_corresponding":false},{"id":130584,"name":"J. P. GEORGE","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"744924","pmcid":null,"openalex_id":"https://openalex.org/W2091171350","authors":[],"funders":[],"total_grants":0,"fwci":1.7857,"citation_percentile":0.84213209,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://joe.bioscientifica.com/view/journals/joe/79/3/joe_79_3_002.xml","host_type":"publisher"},{"url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/79/3/joe_79_3_002.xml","host_type":"publisher"},{"url":"https://doi.org/10.1677/joe.0.0790271","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/744924","host_type":"repository"}],"fields_of_study":["Electrolyte and hormonal disorders","Diet and metabolism studies","Hormonal Regulation and Hypertension","Biology","Medicine","Aging","Ammonia","Animals","Carbon Dioxide","Castration","Female","Glutamine","In Vitro Techniques","Kidney Cortex","Male","Oxygen Consumption","Rats","Sex Factors"],"mesh_terms":["Aging","Ammonia","Animals","Carbon Dioxide","Castration","Female","Glutamine","Kidney Cortex","Male","Oxygen Consumption","Sex Factors","Rats","In Vitro Techniques"],"keywords":["Glutamine","Metabolism","Internal medicine","Endocrinology","Kidney","Ammonia","Biology","Hormone","Castration","Testosterone (patch)","Chemistry","Biochemistry","Medicine","Amino acid"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-04T02:08:01.525282Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}