{"doi":"10.1677/joe.0.0470231","title":"ADRENAL FUNCTION IN BREAST CANCER: BIOGENESIS OF ANDROGENS AND CORTISOL BY THE HUMAN ADRENAL GLAND\n                    <i>IN VIVO</i>","abstract":"<jats:title>SUMMARY</jats:title>\n                  <jats:p>A variety of 14C and 3H-labelled steroids have been perfused through the human adrenal gland in situ and their metabolic products isolated from adrenal venous blood.</jats:p>\n                  <jats:p>Progesterone, dehydroepiandrosterone and cortisol were isolated after infusion of [3H]pregnenolone; 17α-hydroxyprogesterone, dehydroepiandrosterone and cortisol after infusion of [3H]17α-hydroxypregnenolone and [14C]progesterone; androstenedione and cortisol after infusion of [3H]17α-hydroxyprogesterone and [14C]dehydroepiandrosterone; and 11β-hydroxyandrostenedione after infusion of [3H]androstenedione and [14C]cortisol.</jats:p>\n                  <jats:p>From a consideration of the incorporation of radioactivity into the metabolic products, the3H: 14C ratios and the tissue pool sizes it was concluded that the major biosynthetic pathway to cortisol in the human adrenal glands was: pregnenolone→ 17α-hydroxypregnenolone → cortisol. Progesterone was not an important intermediary.</jats:p>\n                  <jats:p>Androstenedione was mainly formed by way of 17α-hydroxypregnenolone → 17α-hydroxyprogesterone → androstenedione. 11β-Hydroxyandrostenedione was formed mainly from cortisol and only a minor amount came from the hydroxylation of androstenedione.</jats:p>","journal":"Journal of Endocrinology","year":1970,"id":589309,"datarank":1.9436385119739417,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":1.5019726650989755,"self_endowment_contribution":0.44166584687496613,"citer_contribution":1.5019726650989755,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":16,"citers_with_citation_signal":16,"citers_with_endowment":16,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1507739,"name":"VIBEKE JENSEN","orcid":null,"position":1,"is_corresponding":false},{"id":1507740,"name":"PAMELA CARSON","orcid":null,"position":2,"is_corresponding":false},{"id":1507741,"name":"R. D. BULBROOK","orcid":null,"position":3,"is_corresponding":false},{"id":183743,"name":"T. W. DOOUSS","orcid":null,"position":4,"is_corresponding":false},{"id":143596,"name":"N. DESHPANDE","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"ADRENAL FUNCTION IN BREAST CANCER: BIOGENESIS OF ANDROGENS AND CORTISOL BY THE HUMAN ADRENAL GLAND\n                    <i>IN VIVO</i>","abstract":"<jats:title>SUMMARY</jats:title>\n                  <jats:p>A variety of 14C and 3H-labelled steroids have been perfused through the human adrenal gland in situ and their metabolic products isolated from adrenal venous blood.</jats:p>\n                  <jats:p>Progesterone, dehydroepiandrosterone and cortisol were isolated after infusion of [3H]pregnenolone; 17α-hydroxyprogesterone, dehydroepiandrosterone and cortisol after infusion of [3H]17α-hydroxypregnenolone and [14C]progesterone; androstenedione and cortisol after infusion of [3H]17α-hydroxyprogesterone and [14C]dehydroepiandrosterone; and 11β-hydroxyandrostenedione after infusion of [3H]androstenedione and [14C]cortisol.</jats:p>\n                  <jats:p>From a consideration of the incorporation of radioactivity into the metabolic products, the3H: 14C ratios and the tissue pool sizes it was concluded that the major biosynthetic pathway to cortisol in the human adrenal glands was: pregnenolone→ 17α-hydroxypregnenolone → cortisol. Progesterone was not an important intermediary.</jats:p>\n                  <jats:p>Androstenedione was mainly formed by way of 17α-hydroxypregnenolone → 17α-hydroxyprogesterone → androstenedione. 11β-Hydroxyandrostenedione was formed mainly from cortisol and only a minor amount came from the hydroxylation of androstenedione.</jats:p>","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4246998","pmcid":null,"openalex_id":"https://openalex.org/W2063032931","authors":[],"funders":[],"total_grants":0,"fwci":1.4856,"citation_percentile":0.817418,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://joe.bioscientifica.com/view/journals/joe/47/2/joe_47_2_011.xml","host_type":"publisher"},{"url":"https://journals.bioscientifica.com/joe/article-pdf/47/2/231/56520/joe_47_2_011.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1677/joe.0.0470231","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/4246998","host_type":"repository"}],"fields_of_study":["Hormonal Regulation and Hypertension","Estrogen and related hormone effects","Hormonal and reproductive studies"],"mesh_terms":["Adrenal Glands","Adrenalectomy","Adult","Aged","Androgens","Androstanes","Androsterone","Breast Neoplasms","Carbon Isotopes","Chromatography, Gas","Chromatography, Paper","Dehydroepiandrosterone","Female","Humans","Hydrocortisone","17-alpha-Hydroxypregnenolone","Hydroxyprogesterones","Middle Aged","Ovary","Pregnenolone","Progesterone","Radioisotope Dilution Technique","Tritium","17-Ketosteroids"],"keywords":["Androstenedione","Pregnenolone","Endocrinology","Dehydroepiandrosterone","Internal medicine","Hydroxyprogesterone","Adrenal gland","Chemistry","Estrone","Hydrocortisone","In vivo","Biology","Androgen","Medicine","Steroid","Hormone"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-23T16:08:35.427794Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}