{"doi":"10.1667/rade-23-00126.1","title":"Single-fraction Radiation Treatment Dose Response in a Genetically Engineered Mouse Model of Medulloblastoma","abstract":"Medulloblastoma is the most common malignant brain tumor of children. Although standard of care radiotherapy for pediatric medulloblastoma (PM) can lead to long-term remission or cure in many patients, it can also cause life-long cognitive impairment and other adverse effects. The pathophysiological mechanisms involved in radiation-induced cerebral damage are incompletely understood, and their elucidation may lead to interventions that mitigate radiation toxicity. To explore the mechanisms of radiation-induced cerebral damage, transgenic mouse models of PM and non-tumor-bearing controls were exposed to radiation doses that ranged from 0 to 30 Gy. Between 0-20 Gy, a significant dose-dependent reduction in tumor-associated hydrocephalus and increase in overall survival were observed. However, at 30 Gy, hydrocephalus incidence increased and median overall survival fell to near-untreated levels. Immunohistochemistry revealed that both tumor-bearing and non-tumor-bearing mice treated with 30 Gy of radiation had significantly more reactive astrocytes and microvascular damage compared to untreated controls. This effect was persistent across mice that were given 1 and 2 weeks of recovery time after irradiation. Our data suggest that radiation therapy promotes neural death by inducing long-term neuroinflammation in PM, suggesting radiation delivery methods that limit inflammation may be effective at widening the therapeutic window of radiation therapy in PM patients.","journal":"Radiation Research","year":2023,"id":385650,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9546,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":926838,"name":"Connor E. Stewart","orcid":"0000-0003-1115-2272","position":1,"is_corresponding":false},{"id":491684,"name":"Nerissa T. Williams","orcid":"0000-0003-0554-9222","position":2,"is_corresponding":false},{"id":491683,"name":"Yan Ma","orcid":"0000-0002-1649-8849","position":3,"is_corresponding":false},{"id":491682,"name":"Lixia Luo","orcid":"0000-0002-8413-0501","position":4,"is_corresponding":false},{"id":927297,"name":"Debosir Ghosh","orcid":null,"position":5,"is_corresponding":false},{"id":1088905,"name":"Loren B. Weidenhammer","orcid":"0009-0000-9127-7272","position":6,"is_corresponding":false},{"id":536197,"name":"Scott Floyd","orcid":"0000-0002-8067-2426","position":7,"is_corresponding":false},{"id":263103,"name":"Yi Fan","orcid":"0000-0002-6290-0595","position":8,"is_corresponding":false},{"id":334422,"name":"David G. Kirsch","orcid":"0000-0002-2086-205X","position":9,"is_corresponding":false},{"id":873699,"name":"Mark Oldham","orcid":"0000-0002-0981-7522","position":10,"is_corresponding":false},{"id":1400,"name":"Zachary J. Reitman","orcid":"0000-0002-9122-9550","position":11,"is_corresponding":false},{"id":1153652,"name":"Kevin J. Tu","orcid":"0000-0002-0089-3932","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-19T01:17:52.636565Z","pmid":"37990957","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}