{"doi":"10.1634/theoncologist.2009-0019","title":"Clinical Experience with Aurora Kinase Inhibitors: A Review","abstract":"<jats:title>Abstract</jats:title><jats:p>The aurora kinase family of serine/threonine kinases comprises three members, designated auroras A, B, and C. Auroras A and B are essential components of the mitotic pathway, ensuring proper chromosome assembly, formation of the mitotic spindle, and cytokinesis. The role of aurora C is less clear. Overexpression of aurora A and B has been observed in several tumor types, and has been linked with a poor prognosis of cancer patients. Several small molecules targeting aurora kinases A and B or both have been evaluated preclinically and in early phase I trials. In this review we aim to summarize the most recent advances in the development of aurora kinase inhibitors, with a focus on the clinical data.</jats:p>","journal":"The Oncologist","year":2009,"id":689399,"datarank":0.6980940525236285,"base_score":4.653960350157523,"endowment":4.653960350157523,"self_citation_contribution":0.6980940525236285,"citation_network_contribution":0.0,"self_endowment_contribution":0.6980940525236285,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":104,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1528828,"name":"Jos H. Beijnen","orcid":null,"position":1,"is_corresponding":false},{"id":89422,"name":"Jan H.M. Schellens","orcid":"0000-0001-6832-1976","position":2,"is_corresponding":false},{"id":89412,"name":"David S. Boss","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinical Experience with Aurora Kinase Inhibitors: A Review","abstract":"<jats:title>Abstract</jats:title><jats:p>The aurora kinase family of serine/threonine kinases comprises three members, designated auroras A, B, and C. Auroras A and B are essential components of the mitotic pathway, ensuring proper chromosome assembly, formation of the mitotic spindle, and cytokinesis. The role of aurora C is less clear. Overexpression of aurora A and B has been observed in several tumor types, and has been linked with a poor prognosis of cancer patients. Several small molecules targeting aurora kinases A and B or both have been evaluated preclinically and in early phase I trials. In this review we aim to summarize the most recent advances in the development of aurora kinase inhibitors, with a focus on the clinical data.</jats:p>","is_dataset_classified":null,"base_score":4.653960350157523,"endowment":4.653960350157523,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19684075","pmcid":null,"openalex_id":"https://openalex.org/W2098615262","authors":[],"funders":[],"total_grants":0,"fwci":3.6817,"citation_percentile":0.93394277,"influential_citations":0,"citation_trend":[{"year":2012,"count":13},{"year":2013,"count":10},{"year":2014,"count":9},{"year":2015,"count":8},{"year":2016,"count":8},{"year":2017,"count":9},{"year":2018,"count":5},{"year":2019,"count":5},{"year":2020,"count":6},{"year":2021,"count":3},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":3},{"year":2025,"count":2}],"oa_status":"bronze","license":"public-domain","oa_locations":[{"url":"https://academic.oup.com/oncolo/article-pdf/14/8/780/41841654/oncolo_14_8_780.pdf","host_type":"journal"},{"url":"https://academic.oup.com/oncolo/article-pdf/14/8/780/41841654/oncolo_14_8_780.pdf","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1634/theoncologist.2009-0019","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1634/theoncologist.2009-0019","host_type":"publisher"},{"url":"https://doi.org/10.1634/theoncologist.2009-0019","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19684075","host_type":"repository"}],"fields_of_study":["Microtubule and mitosis dynamics","Cancer-related Molecular Pathways","Neuroblastoma Research and Treatments"],"mesh_terms":["Animals","Humans","Neoplasms","Protein Serine-Threonine Kinases","Protein Kinase Inhibitors","Aurora Kinase C","Aurora Kinases"],"keywords":["Aurora kinase","Aurora B kinase","Aurora inhibitor","Cytokinesis","Kinase","Medicine","Mitosis","Protein-Serine-Threonine Kinases","Aurora A kinase","Cancer research","Cell biology","Protein kinase A","Cancer","Cell cycle","Biology","Genetics","Internal medicine","Cell","Cell division"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-21T09:19:52.584545Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}