{"doi":"10.1620/tjem.87.155","title":"Idiopathic Hypercholesterolemia: Demonstration of an Impaired Feedback Control of Cholesterol Synthesis <i>in vivo</i>","abstract":null,"journal":"The Tohoku Journal of Experimental Medicine","year":1965,"id":679667,"datarank":0.5416376868966337,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"self_citation_contribution":0.5416376868966337,"citation_network_contribution":0.0,"self_endowment_contribution":0.5416376868966337,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1775829,"name":"Haruko Hirono","orcid":null,"position":1,"is_corresponding":false},{"id":1775830,"name":"Tsuneo Arakawa","orcid":null,"position":2,"is_corresponding":false},{"id":1775828,"name":"Tetsuro Fujiwara","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Idiopathic Hypercholesterolemia: Demonstration of an Impaired Feedback Control of Cholesterol Synthesis <i>in vivo</i>","abstract":"The influence of dietary cholesterol on the synthesis of cholesterol by the liver was studied in liver biopsy samples from human infants. Dietary cholesterol in amounts of 3 to 4g per day suppressed almost completely the synthesis of cholesterol by the liver. Acetate-C14 was orally administered to the infants fed normal or high-cholesterol diet, and the appearance of labeled lipids in the plasma was studied. The feeding of cholesterol depressed the incorporation of acetate-C14 into the plasma cholesterol fraction. In a patient with idiopathic hypercholesterolemia, the feeding of cholesterol had no inhibitory effect upon the incorporation of acetate-C14 into the plasma cholesterol fraction. The results of these studies indicate that infants do normally possess a feedback control of hepatic cholesterol synthesis and that this mechanism is impaired in an infant with idiopathic hypercholesterolemia.","is_dataset_classified":null,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"5893476","pmcid":null,"openalex_id":"https://openalex.org/W1996118476","authors":[],"funders":[],"total_grants":0,"fwci":4.6978,"citation_percentile":0.93539569,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/tjem1920/87/2/87_2_155/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/tjem1920/87/2/87_2_155/_pdf","host_type":"BRONZE"},{"url":"https://www.jstage.jst.go.jp/article/tjem1920/87/2/87_2_155/_pdf","host_type":"publisher"},{"url":"http://www.jstage.jst.go.jp/article/tjem1920/87/2/87_2_155/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.1620/tjem.87.155","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/5893476","host_type":"repository"}],"fields_of_study":["Cholesterol and Lipid Metabolism","Lipoproteins and Cardiovascular Health","Caveolin-1 and cellular processes","Medicine","Animals","Child, Preschool","Cholesterol","Feedback","Humans","Hypercholesterolemia","In Vitro Techniques","Infant","Male"],"mesh_terms":["Animals","Child, Preschool","Cholesterol","Feedback","Humans","Hypercholesterolemia","Infant","Male","In Vitro Techniques"],"keywords":["Cholesterol","Cholesterol synthesis","Internal medicine","In vivo","Endocrinology","Liver biopsy","Chemistry","Medicine","Biopsy","Biology","Biochemistry","Enzyme","Biotechnology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T13:35:54.652876Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}