{"doi":"10.1620/tjem.174.209","title":"Processing and Secretion of Alzheimer's Disease Amyloid Precursor Protein.","abstract":null,"journal":"The Tohoku Journal of Experimental Medicine","year":1994,"id":600082,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1538239,"name":"HIROSHI KITAGAKI","orcid":null,"position":1,"is_corresponding":false},{"id":1538240,"name":"TADATOSHI KINOUCHI","orcid":null,"position":2,"is_corresponding":false},{"id":1538241,"name":"MASAMICHI OKANO","orcid":null,"position":3,"is_corresponding":false},{"id":1538242,"name":"HIROYUKI SORIMACHI","orcid":null,"position":4,"is_corresponding":false},{"id":1538243,"name":"SHOICHI ISHIURA","orcid":null,"position":5,"is_corresponding":false},{"id":1538244,"name":"KOICHI SUZUKI","orcid":null,"position":6,"is_corresponding":false},{"id":1538238,"name":"KAYOKO KINBARA","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Processing and Secretion of Alzheimer's Disease Amyloid Precursor Protein.","abstract":"KINBARA, K., KITAGAKI, H., KINOUCHI, T., OKANO, M., SORIMACHI, H., ISHIURA, S. and SUZUKI, K. Processing and Secretion of Alzheimers's Disease Amyloid Precursor Protein. Tohoku J. Exp. Med., 1994, 174 (3), 209-216 - We studied in vivo expression and in vitro secretion of the Alzheimer's disease amyloid precursor protein (APP). The results indicate that secretion of APP is mediated by PKC and the initial step of the processing may occur in the acidic secretooy granules of the glial cells. Our results suggest that a metabolic switch of APP in neural cells is critical in amyloid deposition.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7761986","pmcid":null,"openalex_id":"https://openalex.org/W2021832975","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.10423654,"influential_citations":0,"citation_trend":[{"year":2012,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/tjem1920/174/3/174_3_209/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/tjem1920/174/3/174_3_209/_pdf","host_type":"publisher"},{"url":"http://www.jstage.jst.go.jp/article/tjem1920/174/3/174_3_209/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.1620/tjem.174.209","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7761986","host_type":"repository"}],"fields_of_study":["Alzheimer's disease research and treatments","Prion Diseases and Protein Misfolding","Amyloidosis: Diagnosis, Treatment, Outcomes","Alzheimer Disease","Amino Acid Sequence","Amyloid Precursor Protein Secretases","Amyloid beta-Peptides","Amyloid beta-Protein Precursor","Animals","Aspartic Acid Endopeptidases","Astrocytes","Brain","Cathepsin B","Cathepsins","Endopeptidases","Glioblastoma","Humans","Lysosomes","Molecular Sequence Data","Neoplasm Proteins","Nerve Tissue Proteins","Peptide Fragments","Phosphorylation","Protein Kinase C","Protein Processing, Post-Translational","Rats","Substrate Specificity","Tumor Cells, Cultured"],"mesh_terms":["Alzheimer Disease","Amino Acid Sequence","Animals","Astrocytes","Brain","Cathepsin B","Cathepsins","Glioblastoma","Humans","Lysosomes","Molecular Sequence Data","Neoplasm Proteins","Nerve Tissue Proteins","Peptide Fragments","Endopeptidases","Phosphorylation","Protein Kinase C","Protein Processing, Post-Translational","Substrate Specificity","Tumor Cells, Cultured","Amyloid beta-Peptides","Aspartic Acid Endopeptidases","Amyloid beta-Protein Precursor","Rats","Amyloid Precursor Protein Secretases"],"keywords":["Secretion","Amyloid precursor protein","Alzheimer's disease","P3 peptide","Amyloid (mycology)","In vivo","Chemistry","Cell biology","β amyloid","Amyloid β","Disease","Biochemistry","Biology","Internal medicine","Medicine","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T12:11:34.768756Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}