{"doi":"10.1615/jenvironpatholtoxicoloncol.v27.i3.10","title":"Computational Biology of Genome Expression and Regulation—A Review of Microarray Bioinformatics","abstract":null,"journal":"Journal of Environmental Pathology, Toxicology and Oncology","year":2008,"id":607243,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":438217,"name":"Junbai Wang","orcid":"0000-0001-5505-5613","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Computational Biology of Genome Expression and Regulation—A Review of Microarray Bioinformatics","abstract":"Microarray technology is being used widely in various biomedical research areas; the corresponding microarray data analysis is an essential step toward the best utilizing of array technologies. Here we review two components of the microarray data analysis: a low level of microarray data analysis that emphasizes the designing, the quality control, and the preprocessing of microarray experiments, then a high level of microarray data analysis that focuses on the domain-specific microarray applications such as tumor classification, biomarker prediction, analyzing array CGH experiments, and reverse engineering of gene expression networks. Additionally, we will review the recent development of building a predictive model in genome expression and regulation studies. This review may help biologists grasp a basic knowledge of microarray bioinformatics as well as its potential impact on the future evolvement of biomedical research fields.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18652564","pmcid":null,"openalex_id":"https://openalex.org/W2065186132","authors":[],"funders":[],"total_grants":0,"fwci":0.9098,"citation_percentile":0.72949415,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":1},{"year":2014,"count":2},{"year":2015,"count":3},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://dl.begellhouse.com/download/article/654006685c347b54/JEP2703 (157-179).pdf","host_type":"publisher"},{"url":"https://doi.org/10.1615/jenvironpatholtoxicoloncol.v27.i3.10","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18652564","host_type":"repository"}],"fields_of_study":["Gene expression and cancer classification","Bioinformatics and Genomic Networks","Gene Regulatory Network Analysis"],"mesh_terms":["Gene Expression Regulation","Humans","Genome","Computational Biology","Oligonucleotide Array Sequence Analysis","Gene Expression Profiling"],"keywords":["Microarray databases","Microarray analysis techniques","Microarray","Gene chip analysis","Computational biology","DNA microarray","Preprocessor","Bioinformatics","Computer science","Biology","Gene expression","Gene","Genetics","Artificial intelligence"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T06:01:23.867176Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}