{"doi":"10.1615/critrevimmunol.2019033233","title":"Impact of the Microbiome on the Immune System","abstract":null,"journal":"Critical Reviews in Immunology","year":2019,"id":594048,"datarank":0.6798899239729885,"base_score":4.532599493153256,"endowment":4.532599493153256,"self_citation_contribution":0.6798899239729885,"citation_network_contribution":0.0,"self_endowment_contribution":0.6798899239729885,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":92,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1520536,"name":"Sohail Siraj","orcid":null,"position":1,"is_corresponding":false},{"id":1441645,"name":"Krishna Patel","orcid":"0009-0005-9246-3751","position":2,"is_corresponding":false},{"id":1520537,"name":"Umesh T. Sankpal","orcid":null,"position":3,"is_corresponding":false},{"id":1520538,"name":"Stephen Mathew","orcid":null,"position":4,"is_corresponding":false},{"id":317727,"name":"Riyaz Basha","orcid":"0000-0002-4071-0993","position":5,"is_corresponding":false},{"id":1520535,"name":"Christoffer B. Lambring","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Impact of the Microbiome on the Immune System","abstract":"Higher organisms are all born with general immunity as well as with, increasingly, more specific immune systems. All immune mechanisms function with the intent of aiding the body in defense against infection. Internal and external factors alike have varying effects on the immune system, and the immune response is tailored specifically to each one. Accompanying the components of the human innate and adaptive immune systems are the other intermingling systems of the human body. Increasing understanding of the body's immune interactions with other systems has opened new avenues of study, including that of the microbiome. The microbiome has become a highly active area of research over the last 10 to 20 years since the NIH began funding the Human Microbiome Project (HMP), which was established in 2007. Several publications have focused on the characterization, functions, and complex interplay of the microbiome as it relates to the rest of the body. A dysfunction between the microbiome and the host has been linked to various diseases including cancers, metabolic deficiencies, autoimmune disorders, and infectious diseases. Further understanding of the microbiome and its interaction with the host in relation to diseases is needed in order to understand the implications of microbiome dysfunction and the possible use of microbiota in the prevention of disease. In this review, we have summarized information on the immune system, the microbiome, the microbiome's interplay with other systems, and the association of the immune system and the microbiome in diseases such as diabetes and colorectal cancer.","is_dataset_classified":null,"base_score":4.532599493153256,"endowment":4.532599493153256,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32422014","pmcid":"PMC7362776","openalex_id":"https://openalex.org/W2998677616","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"P20 CA233355","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R25 HL125447","title":null},{"funder_name":"NIH HHS","grant_id":"OT2 OD032581","title":null},{"funder_name":"NIMHD NIH HHS","grant_id":"P20 MD006882","title":null},{"funder_name":"NIMHD NIH HHS","grant_id":"S21 MD012472","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P20 CA233391","title":null},{"funder_name":"NIMHD NIH HHS","grant_id":"U54 MD006882","title":null}],"total_grants":7,"fwci":1.2135,"citation_percentile":0.79295121,"influential_citations":0,"citation_trend":[{"year":2021,"count":9},{"year":2022,"count":7},{"year":2023,"count":11},{"year":2024,"count":37},{"year":2025,"count":22},{"year":2026,"count":6}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7362776","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7362776","host_type":"repository"},{"url":"http://www.dl.begellhouse.com/download/article/0788f832755452dd/(1)CRI-33233.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1615/critrevimmunol.2019033233","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32422014","host_type":"repository"}],"fields_of_study":["Gut microbiota and health","Immune Cell Function and Interaction","Clostridium difficile and Clostridium perfringens research","Animals","Autoimmune Diseases","Host-Pathogen Interactions","Humans","Immune System","Immunity","Infections","Metabolic Diseases","Microbiota","Neoplasms"],"mesh_terms":["Animals","Autoimmune Diseases","Humans","Immune System","Immunity","Infections","Metabolic Diseases","Neoplasms","Host-Pathogen Interactions","Microbiota"],"keywords":["Microbiome","Immune system","Human Microbiome Project","Immunology","Acquired immune system","Immunity","Biology","Innate immune system","Disease","Human microbiome","Medicine","Bioinformatics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T13:18:25.583706Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}