{"doi":"10.1609/aaai.v38i20.30248","title":"Deep Reinforcement Learning for Early Diagnosis of Lung Cancer","abstract":"Lung cancer remains the leading cause of cancer-related death worldwide, and early diagnosis of lung cancer is critical for improving the survival rate of patients. Performing annual low-dose computed tomography (LDCT) screening among high-risk populations is the primary approach for early diagnosis. However, after each screening, whether to continue monitoring (with follow-up screenings) or to order a biopsy for diagnosis remains a challenging decision to make. Continuing with follow-up screenings may lead to delayed diagnosis but ordering a biopsy without sufficient evidence incurs unnecessary risk and cost. In this paper, we tackle the problem by an optimal stopping approach. Our proposed algorithm, called EarlyStop-RL, utilizes the structure of the Snell envelope for optimal stopping, and model-free deep reinforcement learning for making diagnosis decisions. Through evaluating our algorithm on a commonly used clinical trial dataset (the National Lung Screening Trial), we demonstrate that EarlyStop-RL has the potential to greatly enhance risk assessment and early diagnosis of lung cancer, surpassing the performance of two widely adopted clinical models, namely the Lung-RADS and the Brock model.","journal":"Proceedings of the AAAI Conference on Artificial Intelligence","year":2024,"id":485478,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1328494,"name":"Qining Zhang","orcid":"0000-0002-8634-1601","position":1,"is_corresponding":false},{"id":1182199,"name":"Lei Ying","orcid":"0000-0001-7955-9445","position":2,"is_corresponding":false},{"id":455250,"name":"Chuan Zhou","orcid":"0000-0002-0609-1658","position":3,"is_corresponding":false},{"id":571295,"name":"Yifan Wang","orcid":"0000-0002-4519-7535","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T02:07:52.536246Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}