{"doi":"10.1590/0004-282x20180155","title":"A comparison of nontreponemal tests in cerebrospinal fluid for neurosyphilis diagnosis: equivalent detection of specific antibodies","abstract":"<jats:p>ABSTRACT Syphilis is a re-emerging sexually-transmitted infection, caused by the spirochete Treponema pallidum, that may penetrate early into the central nervous system. The venereal disease research laboratory test (VDRL) on the cerebrospinal fluid (CSF) is the most widely used for neurosyphilis diagnosis. We evaluated the performance of two other nontreponemal tests (rapid plasma reagin [RPR] and unheated serum reagin [USR] tests) in comparison with the VDRL in CSF.  Methods: We analyzed CSF samples from 120 individuals based on VDRL reactivity in the CSF and the clinical picture of neurosyphilis.  Results: High inter-rater reliability was found among all three tests, with equivalent sensitivity and specificity. Intraclass correlation coefficient for absolute agreement was 1 for VDRL versus USR, 0.99 for VDRL versus RPR, and 0.99 for RPR versus USR.  Conclusions: Rapid plasma reagin and unheated serum reagin tests were identified as excellent alternatives for neurosyphilis diagnosis.</jats:p>","journal":"Arquivos de Neuro-Psiquiatria","year":2019,"id":688564,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":6,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1798882,"name":"Mauro Jorge Cabral-Castro","orcid":null,"position":1,"is_corresponding":false},{"id":1798883,"name":"Marzia Puccioni-Sohler","orcid":"0000-0001-6007-9142","position":2,"is_corresponding":false},{"id":1798881,"name":"Isadora Versiani","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A comparison of nontreponemal tests in cerebrospinal fluid for neurosyphilis diagnosis: equivalent detection of specific antibodies","abstract":"<jats:p>ABSTRACT Syphilis is a re-emerging sexually-transmitted infection, caused by the spirochete Treponema pallidum, that may penetrate early into the central nervous system. The venereal disease research laboratory test (VDRL) on the cerebrospinal fluid (CSF) is the most widely used for neurosyphilis diagnosis. We evaluated the performance of two other nontreponemal tests (rapid plasma reagin [RPR] and unheated serum reagin [USR] tests) in comparison with the VDRL in CSF.  Methods: We analyzed CSF samples from 120 individuals based on VDRL reactivity in the CSF and the clinical picture of neurosyphilis.  Results: High inter-rater reliability was found among all three tests, with equivalent sensitivity and specificity. Intraclass correlation coefficient for absolute agreement was 1 for VDRL versus USR, 0.99 for VDRL versus RPR, and 0.99 for RPR versus USR.  Conclusions: Rapid plasma reagin and unheated serum reagin tests were identified as excellent alternatives for neurosyphilis diagnosis.</jats:p>","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":6,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30810592","pmcid":null,"openalex_id":"https://openalex.org/W2917025890","authors":[],"funders":[],"total_grants":0,"fwci":0.9612,"citation_percentile":0.74134047,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":5},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1590/0004-282x20180155","host_type":"journal"},{"url":"https://doi.org/10.1590/0004-282x20180155","host_type":"publisher"},{"url":"http://www.scielo.br/pdf/anp/v77n2/1678-4227-anp-77-02-0091.pdf","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30810592","host_type":"repository"},{"url":"http://old.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0004-282X2019000200091","host_type":"repository"},{"url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2653119","host_type":"repository"},{"url":"https://doaj.org/article/cc47c222c0dc4d6a9fa6a1c59df032d4","host_type":"repository"}],"fields_of_study":["Syphilis Diagnosis and Treatment","Reproductive tract infections research","Virology and Viral Diseases","Adult","Analysis of Variance","Antibodies, Bacterial","Case-Control Studies","Female","Humans","Male","Middle Aged","Neurosyphilis","Reference Values","Reproducibility of Results","Sensitivity and Specificity","Statistics, Nonparametric","Syphilis Serodiagnosis"],"mesh_terms":["Adult","Analysis of Variance","Antibodies, Bacterial","Female","Humans","Male","Middle Aged","Neurosyphilis","Reference Values","Sensitivity and Specificity","Syphilis Serodiagnosis","Reproducibility of Results","Case-Control Studies","Statistics, Nonparametric"],"keywords":["Rapid plasma reagin","Neurosyphilis","Treponema","Medicine","Syphilis","Cerebrospinal fluid","Syphilis Serodiagnosis","Immunology","Internal medicine","Pathology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.14782513.v1","title":"Additional file 1 of Diagnostic tools for neurosyphilis: a systematic review","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14782513","title":"Additional file 1 of Diagnostic tools for neurosyphilis: a systematic review","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14782516.v1","title":"Additional file 2 of Diagnostic tools for neurosyphilis: a systematic review","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14782516","title":"Additional file 2 of Diagnostic tools for neurosyphilis: a systematic review","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.7773752.v1","title":"A comparison of nontreponemal tests in cerebrospinal fluid for neurosyphilis diagnosis: equivalent detection of specific antibodies","publisher":"SciELO journals","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.7773752","title":"A comparison of nontreponemal tests in cerebrospinal fluid for neurosyphilis diagnosis: equivalent detection of specific antibodies","publisher":"SciELO journals","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T17:31:35.194124Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}