{"doi":"10.1586/17512433.2014.893818","title":"Riociguat for pulmonary hypertension","abstract":null,"journal":"Expert Review of Clinical Pharmacology","year":2014,"id":619848,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1417540,"name":"Joanna Pepke-Zaba","orcid":null,"position":1,"is_corresponding":false},{"id":1599837,"name":"John E Cannon","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Riociguat for pulmonary hypertension","abstract":"Pulmonary hypertension, an elevation of the mean pulmonary artery pressure ≥25 mmHg, ultimately leads to premature death due to right ventricular dysfunction. Ten treatments from three classes of drugs are licensed for the management of pulmonary arterial hypertension. These treatments have improved exercise capacity but median survival is still poor. Additionally there are no licensed therapies for the other groups of pulmonary hypertension. Riociguat is a novel drug that stimulates soluble guanylate cyclase independently of nitric oxide and in synergy with nitric oxide. This review summarises the available evidence for riociguat in the treatment across all groups of pulmonary hypertension with a focus on pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24580082","pmcid":null,"openalex_id":"https://openalex.org/W2003581967","authors":[],"funders":[],"total_grants":0,"fwci":1.7753,"citation_percentile":0.84572867,"influential_citations":0,"citation_trend":[{"year":2014,"count":3},{"year":2015,"count":2},{"year":2016,"count":3},{"year":2021,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.tandfonline.com/doi/pdf/10.1586/17512433.2014.893818","host_type":"publisher"},{"url":"https://doi.org/10.1586/17512433.2014.893818","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24580082","host_type":"repository"}],"fields_of_study":["Pulmonary Hypertension Research and Treatments","Cardiovascular Issues in Pregnancy","Cardiovascular Function and Risk Factors","Animals","Clinical Trials as Topic","Drug Evaluation, Preclinical","Guanylate Cyclase","Hemodynamics","Humans","Hypertension, Pulmonary","Nitric Oxide","Pyrazoles","Pyrimidines","Treatment Outcome","Vasodilator Agents"],"mesh_terms":["Animals","Clinical Trials as Topic","Drug Evaluation, Preclinical","Guanylate Cyclase","Hemodynamics","Humans","Hypertension, Pulmonary","Nitric Oxide","Pyrazoles","Pyrimidines","Vasodilator Agents","Treatment Outcome"],"keywords":["Riociguat","Medicine","Pulmonary hypertension","Cardiology","Nitric oxide","Pulmonary artery","Chronic thromboembolic pulmonary hypertension","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"},{"sdg_number":0,"sdg_label":"No poverty"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T08:51:00.223395Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}