{"doi":"10.15585/mmwr.mm6940e1","title":"Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection — United Kingdom and United States, March–August 2020","abstract":"During the course of the coronavirus disease 2019 (COVID-19) pandemic, reports of a new multisystem inflammatory syndrome in children (MIS-C) have been increasing in Europe and the United States (1-3). Clinical features in children have varied but predominantly include shock, cardiac dysfunction, abdominal pain, and elevated inflammatory markers, including C-reactive protein (CRP), ferritin, D-dimer, and interleukin-6 (1). Since June 2020, several case reports have described a similar syndrome in adults; this review describes in detail nine patients reported to CDC, seven from published case reports, and summarizes the findings in 11 patients described in three case series in peer-reviewed journals (4-6). These 27 patients had cardiovascular, gastrointestinal, dermatologic, and neurologic symptoms without severe respiratory illness and concurrently received positive test results for SARS-CoV-2, the virus that causes COVID-19, by polymerase chain reaction (PCR) or antibody assays indicating recent infection. Reports of these patients highlight the recognition of an illness referred to here as multisystem inflammatory syndrome in adults (MIS-A), the heterogeneity of clinical signs and symptoms, and the role for antibody testing in identifying similar cases among adults. Clinicians and health departments should consider MIS-A in adults with compatible signs and symptoms. These patients might not have positive SARS-CoV-2 PCR or antigen test results, and antibody testing might be needed to confirm previous SARS-CoV-2 infection. Because of the temporal association between MIS-A and SARS-CoV-2 infections, interventions that prevent COVID-19 might prevent MIS-A. Further research is needed to understand the pathogenesis and long-term effects of this newly described condition.","journal":"MMWR Morbidity and Mortality Weekly Report","year":2020,"id":48176,"datarank":0.9392237526481564,"base_score":6.261491684321042,"endowment":6.261491684321042,"self_citation_contribution":0.9392237526481564,"citation_network_contribution":0.0,"self_endowment_contribution":0.9392237526481564,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":523,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9411,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":226688,"name":"Noah G. Schwartz","orcid":"0000-0002-2252-1646","position":1,"is_corresponding":false},{"id":226689,"name":"Pragna Patel","orcid":"0000-0003-1386-8194","position":2,"is_corresponding":false},{"id":226690,"name":"Lilian M. Abbo","orcid":"0000-0002-2364-8358","position":3,"is_corresponding":false},{"id":229490,"name":"Laura Beauchamps","orcid":null,"position":4,"is_corresponding":false},{"id":226691,"name":"Shuba Balan","orcid":"0000-0002-2124-5432","position":5,"is_corresponding":false},{"id":229491,"name":"Ellen H. Lee","orcid":null,"position":6,"is_corresponding":false},{"id":229492,"name":"Rachel Paneth-Pollak","orcid":null,"position":7,"is_corresponding":false},{"id":229493,"name":"Anita Geevarughese","orcid":null,"position":8,"is_corresponding":false},{"id":226692,"name":"Maura K. Lash","orcid":"0000-0001-9855-5503","position":9,"is_corresponding":false},{"id":229494,"name":"Marie Dorsinville","orcid":null,"position":10,"is_corresponding":false},{"id":229495,"name":"Vennus Ballen","orcid":null,"position":11,"is_corresponding":false},{"id":229496,"name":"Daniel Eiras","orcid":null,"position":12,"is_corresponding":false},{"id":53949,"name":"Christopher Newton‐Cheh","orcid":"0000-0002-3001-9111","position":13,"is_corresponding":false},{"id":229497,"name":"Emer Smith","orcid":null,"position":14,"is_corresponding":false},{"id":226693,"name":"Sara Robinson","orcid":"0000-0001-9849-6785","position":15,"is_corresponding":false},{"id":229498,"name":"Patricia Stogsdill","orcid":null,"position":16,"is_corresponding":false},{"id":226694,"name":"Sarah Lim","orcid":"0000-0001-8897-3891","position":17,"is_corresponding":false},{"id":226695,"name":"Sharon Fox","orcid":"0000-0002-0766-5393","position":18,"is_corresponding":false},{"id":226696,"name":"Gillian Richardson","orcid":"0000-0002-5601-3447","position":19,"is_corresponding":false},{"id":229499,"name":"Julie Hand","orcid":null,"position":20,"is_corresponding":false},{"id":229500,"name":"Nora Oliver","orcid":null,"position":21,"is_corresponding":false},{"id":226697,"name":"Aaron Kofman","orcid":"0000-0002-7507-6355","position":22,"is_corresponding":false},{"id":226698,"name":"Bobbi Bryant","orcid":"0000-0002-6357-6168","position":23,"is_corresponding":false},{"id":226699,"name":"Zachary Ende","orcid":"0000-0002-0721-6205","position":24,"is_corresponding":false},{"id":229501,"name":"Deblina Datta","orcid":null,"position":25,"is_corresponding":false},{"id":226700,"name":"Ermias D. Belay","orcid":"0000-0002-9837-0960","position":26,"is_corresponding":false},{"id":226701,"name":"Shana Godfred‐Cato","orcid":"0000-0002-4106-0953","position":27,"is_corresponding":false},{"id":226687,"name":"Sapna Bamrah Morris","orcid":"0000-0002-2493-1411","position":0,"is_corresponding":true}],"reference_count":9,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T20:34:12.647743Z","pmid":"33031361","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}