{"doi":"10.1542/peds.74.1.1","title":"Bronchiolitis as a Possible Cause of Wheezing in Childhood: New Evidence","abstract":"<jats:p>A historical cohort study was performed in order to assess the hypothesis that even mild bronchiolitis in infancy is a predictor of wheezing later in childhood. Subjects who had experienced bronchiolitis and a matched control group were compared in terms of reported wheezing 8 years later. A highly significant difference was found between the bronchiolitis group and the control group in terms of current wheezing (P &amp;lt; .0001, relative risk 3.24). This difference was maintained after adjusting for many potentially confounding variables including family history of allergy and other allergic manifestations in the child. Results suggested that 13.6% of a normal practice population in the age range 6 to 9 years currently wheeze, but that 44.1% of children who experienced bronchiolitis currently wheeze. Based on the incidence of bronchiolitis (4.27/100 children in their first 2 years of life) and the relative odds for wheezing derived from a logistic regression model including variables that measured passive smoking, genetic tendency to wheeze, and bronchiolitis, calculations of attributable risk suggested that wheezing in 9.4% of the population of children who currently wheeze was attributable to bronchiolitis.</jats:p>","journal":"Pediatrics","year":1984,"id":672127,"datarank":0.7266280629687888,"base_score":4.844187086458591,"endowment":4.844187086458591,"self_citation_contribution":0.7266280629687888,"citation_network_contribution":0.0,"self_endowment_contribution":0.7266280629687888,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":126,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1756022,"name":"Klaus J. Roghmann","orcid":null,"position":1,"is_corresponding":false},{"id":1756023,"name":"Suzanne J. Klein","orcid":null,"position":2,"is_corresponding":false},{"id":1756024,"name":"Thomas K. Mclnery","orcid":null,"position":3,"is_corresponding":false},{"id":1756025,"name":"James B. MacWhinney","orcid":null,"position":4,"is_corresponding":false},{"id":1756026,"name":"Robert L. Miller","orcid":null,"position":5,"is_corresponding":false},{"id":1756027,"name":"Lawrence F. Nazarian","orcid":null,"position":6,"is_corresponding":false},{"id":1756021,"name":"Kenneth M. McConnochie","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Bronchiolitis as a Possible Cause of Wheezing in Childhood: New Evidence","abstract":"<jats:p>A historical cohort study was performed in order to assess the hypothesis that even mild bronchiolitis in infancy is a predictor of wheezing later in childhood. Subjects who had experienced bronchiolitis and a matched control group were compared in terms of reported wheezing 8 years later. A highly significant difference was found between the bronchiolitis group and the control group in terms of current wheezing (P &amp;lt; .0001, relative risk 3.24). This difference was maintained after adjusting for many potentially confounding variables including family history of allergy and other allergic manifestations in the child. Results suggested that 13.6% of a normal practice population in the age range 6 to 9 years currently wheeze, but that 44.1% of children who experienced bronchiolitis currently wheeze. Based on the incidence of bronchiolitis (4.27/100 children in their first 2 years of life) and the relative odds for wheezing derived from a logistic regression model including variables that measured passive smoking, genetic tendency to wheeze, and bronchiolitis, calculations of attributable risk suggested that wheezing in 9.4% of the population of children who currently wheeze was attributable to bronchiolitis.</jats:p>","is_dataset_classified":null,"base_score":4.844187086458591,"endowment":4.844187086458591,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6739202","pmcid":null,"openalex_id":"https://openalex.org/W1574751996","authors":[],"funders":[],"total_grants":0,"fwci":7.1451,"citation_percentile":0.97181593,"influential_citations":0,"citation_trend":[{"year":2013,"count":4},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://publications.aap.org/pediatrics/article-pdf/74/1/1/1034205/1.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1542/peds.74.1.1","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6739202","host_type":"repository"}],"fields_of_study":["Neonatal Respiratory Health Research","Respiratory viral infections research","Respiratory Support and Mechanisms"],"mesh_terms":["Adolescent","Asthma","Bronchiolitis, Viral","Bronchitis","Child","Child, Preschool","Humans","Infant","Probability","Respiratory Sounds","Retrospective Studies","Risk","Seasons"],"keywords":["Bronchiolitis","Wheeze","Medicine","Pediatrics","Asthma","Respiratory sounds","Population","Cohort","Incidence (geometry)","Odds ratio","Cohort study","Confounding","Internal medicine","Environmental health","Respiratory system"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T06:38:53.735275Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}