{"doi":"10.1542/peds.44.6.905","title":"SINGLE INJECTION CLEARANCE IN CHILDREN","abstract":"<jats:p>The renal clearance of sodium iothalamate I125 after a single intravenous dose of 10 to 25 µCi was calculated from the plasma disappearance curve. The endogenous creatinine clearance was compared with these results. Thirty-eight studies in 35 pediatric patients with all levels of renal function were performed. Eight studies were excluded because of grossly incomplete urine collection, and 5 studies were not analyzed further because of very low glomerular filtration rate. The correlation between both methods in the 21 studies was good (Ccreat = 0.91 x Csi + 4.9, r = 0.91). It was significantly better in the nine patients with a serum creatinine of 0.7 mg/100 ml or more (Ccreat = 1.01 x Csi — 1.2, r = 0.97) than in the 16 patients with a serum creatinine of 0.6 mg/100 ml or less (Ccreat = 0.82 x Csi + 11.5, r = 0.84). In the latter group, the accuracy of the serum creatinine determination was often poor, and even variations of ± 0.1 mg/100 ml could lead to a gross error in the calculation of the clearance.</jats:p>\n               <jats:p>In four patients, the clearance was obtained by external counting and agreed well with the clearance calculated from the plasma samples.</jats:p>\n               <jats:p>The single injection clearance is especially indicated in children (1) when no adequate urine collection is obtainable, (2) at low serum creatinine concentrations, and (3) in outpatients.</jats:p>","journal":"Pediatrics","year":1969,"id":632452,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1639399,"name":"Ernst P. Leumann","orcid":null,"position":1,"is_corresponding":false},{"id":1639400,"name":"Malcolm A. Holliday","orcid":null,"position":2,"is_corresponding":false},{"id":1639398,"name":"Tadasu Sakai","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"SINGLE INJECTION CLEARANCE IN CHILDREN","abstract":"<jats:p>The renal clearance of sodium iothalamate I125 after a single intravenous dose of 10 to 25 µCi was calculated from the plasma disappearance curve. The endogenous creatinine clearance was compared with these results. Thirty-eight studies in 35 pediatric patients with all levels of renal function were performed. Eight studies were excluded because of grossly incomplete urine collection, and 5 studies were not analyzed further because of very low glomerular filtration rate. The correlation between both methods in the 21 studies was good (Ccreat = 0.91 x Csi + 4.9, r = 0.91). It was significantly better in the nine patients with a serum creatinine of 0.7 mg/100 ml or more (Ccreat = 1.01 x Csi — 1.2, r = 0.97) than in the 16 patients with a serum creatinine of 0.6 mg/100 ml or less (Ccreat = 0.82 x Csi + 11.5, r = 0.84). In the latter group, the accuracy of the serum creatinine determination was often poor, and even variations of ± 0.1 mg/100 ml could lead to a gross error in the calculation of the clearance.</jats:p>\n               <jats:p>In four patients, the clearance was obtained by external counting and agreed well with the clearance calculated from the plasma samples.</jats:p>\n               <jats:p>The single injection clearance is especially indicated in children (1) when no adequate urine collection is obtainable, (2) at low serum creatinine concentrations, and (3) in outpatients.</jats:p>","is_dataset_classified":null,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19910364","pmcid":null,"openalex_id":"https://openalex.org/W4206255419","authors":[],"funders":[],"total_grants":0,"fwci":5.7124,"citation_percentile":0.95239441,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://publications.aap.org/pediatrics/article-pdf/44/6/905/929545/905.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1542/peds.44.6.905","host_type":"journal"}],"fields_of_study":["Pharmaceutical studies and practices","Pharmacological Effects and Toxicity Studies","Ion Transport and Channel Regulation"],"mesh_terms":[],"keywords":["Medicine","Renal function","Creatinine","Urology","Urine","Plasma clearance","Urine collection device","Clearance","Internal medicine","Endocrinology","Pharmacokinetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"No poverty"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T09:48:10.433326Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}