{"doi":"10.1542/peds.2022-059138","title":"Intraventricular Hemorrhage in Very Preterm Children: Mortality and Neurodevelopment at Age 5","abstract":"OBJECTIVES: The objectives were to describe mortality and causes of death in children with intraventricular hemorrhage (IVH) and to study neurodevelopmental outcomes. METHODS: The study was a secondary analysis of the French national prospective and population-based cohort EPIPAGE-2. Children were recruited in 2011. A standardized assessment was conducted at age 5. Children born before 32 weeks' gestation and admitted to a NICU were eligible. Exposure was IVH defined by the Papile classification. Main outcomes were mortality, causes of death, and neurodevelopmental outcomes at age 5. RESULTS: Among the 3468 children included, 578 (16.7%) had grade 1 IVH, 424 (12.2%) grade 2 IVH, and 114 (3.3%) grade 3 IVH; 144 (4.1%) had intraparenchymal hemorrhage (IPH). Mortality was 29.7% (36 of 114) for children with grade 3 IVH and 74.4% (109 of 144) for those with IPH; 67.6% (21 of 31) and 88.7% (86 of 97) of deaths, respectively, were because of withholding and withdrawing of life-sustaining treatment. As compared with no IVH, low-grade IVH was not associated with measured neurodevelopmental disabilities at age 5. High-grade IVH was associated with moderate and severe neurodevelopmental disabilities, reduced full-scale IQ, and cerebral palsy. CONCLUSIONS: Rates of neurodevelopmental disabilities at age 5 did not differ between children without IVH and those with low-grade IVH. For high-grade IVH, mortality rate was high, mostly because of withholding and withdrawal of life-sustaining treatment, and we found a strong association with overall neurodevelopmental disabilities in survivors.","journal":"PEDIATRICS","year":2023,"id":326465,"datarank":0.9731505030080938,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.46805612851012257,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.46805612851012257,"corpus_percentile":79.18310512880018,"corpus_rank":2692,"citation_count":28,"citer_count":27,"citers_with_citation_signal":13,"citers_with_endowment":13,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5329,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1045485,"name":"Marie Chevallier","orcid":"0000-0002-1589-0144","position":1,"is_corresponding":false},{"id":1045971,"name":"Pierre‐Henri Jarreau","orcid":null,"position":2,"is_corresponding":false},{"id":1045486,"name":"Olivier Baud","orcid":"0000-0001-5021-0522","position":3,"is_corresponding":false},{"id":1045487,"name":"Valérie Benhammou","orcid":"0000-0001-6568-0324","position":4,"is_corresponding":false},{"id":1045972,"name":"Catherine Gire","orcid":null,"position":5,"is_corresponding":false},{"id":1045488,"name":"Laetitia Marchand‐Martin","orcid":"0000-0002-8036-8387","position":6,"is_corresponding":false},{"id":1045489,"name":"Stéphane Marret","orcid":"0000-0002-2858-148X","position":7,"is_corresponding":false},{"id":888541,"name":"Véronique Pierrat","orcid":"0000-0001-7435-5144","position":8,"is_corresponding":false},{"id":1045490,"name":"Pierre‐Yves Ancel","orcid":"0000-0001-9632-7494","position":9,"is_corresponding":false},{"id":1045491,"name":"Héloïse Torchin","orcid":"0000-0003-4699-5384","position":10,"is_corresponding":false},{"id":1045484,"name":"Ludovic Tréluyer","orcid":"0000-0001-8171-1311","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T01:08:33.106703Z","pmid":"36919442","pmcid":"PMC10071431","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}