{"doi":"10.1542/peds.2018-2420ddd","title":"Changes in Patient Quality of Life During Oral Immunotherapy for Food Allergy","abstract":null,"journal":"Pediatrics","year":2018,"id":650975,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1003790,"name":"Elinor Simons","orcid":"0000-0002-1620-2606","position":1,"is_corresponding":false},{"id":1697630,"name":"Salma Bahreinian","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Changes in Patient Quality of Life During Oral Immunotherapy for Food Allergy","abstract":"In this study, the authors examined how quality of life (QoL) changes for children with food allergy during the up-dosing build phase of oral immunotherapy (OIT).There were 155 children age 4 to 12 years (median age: 5 years) with immunoglobulin E–mediated food allergy to milk, peanuts, or eggs enrolled in OIT, and 41 age-matched children (median age: 7 years) with food allergy who did not undergo OIT were included as controls.During the OIT induction phases, the maximal-tolerated dose (MTD) without a reaction was established for each child, and this dose was consumed twice daily during the home-treatment phase until the next induction cycle, at which time the MTD was increased as tolerated. Parents completed the Food Allergy Quality of Life Questionnaire Parent Form during the initial induction week and again at the median time point (4 months). QoL of controls were measured at 2 time points 16 months apart.Food anxiety, social and dietary limitation, and total Food Allergy Quality of Life Questionnaire Parent Form scores improved in children enrolled in OIT but not in controls; emotional impact did not improve. Food anxiety and labeling concerns improved clinically, and limitation placed by food allergy on the child’s life was the single question revealing deterioration. Children with worse QoL at baseline improved, whereas those with better QoL at baseline deteriorated. Participant QoL scores were divided into 3 groups: significant worsening (23%), nonsignificant change (37%), and significant improvement (39%). Demographics, pre-OIT reaction severity, pace of advancing through OIT, build-up versus maintenance phase of OIT, MTD, and rate of reactions or epinephrine use during OIT did not differ among the 3 groups.Despite the burden of treatment, QoL of children with food allergy improved during OIT in those with impaired QoL at baseline. QoL of children who started with better QoL at baseline deteriorated during OIT, suggesting that physicians should better prepare families for OIT.QoL of children and families has been shown to improve after the successful completion of OIT. In this study, the authors examined QoL changes among individual children still in the build-up phase of OIT compared with their baseline QoL and showed that QoL may deteriorate during OIT, particularly in children who start with better QoL and regarding limitations placed by food allergy on the child’s life. Deteriorating QoL may significantly affect adherence, a known limitation of OIT. Providing relevant counseling on the challenges of OIT and its impact on QoL, in conjunction with professional emotional and psychological support, may have a pivotal role in improving adherence. These findings may be used to guide the selection of families who will need more support during OIT when the support is most needed. Additional data regarding the short- and long-term changes in QoL during OIT may help to improve its effectiveness.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19965766","pmcid":null,"openalex_id":"https://openalex.org/W2903258130","authors":[],"funders":[],"total_grants":0,"fwci":0.1512,"citation_percentile":0.53049624,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://publications.aap.org/pediatrics/article-pdf/142/Supplement_4/S242/913608/peds_20182420ddd.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1542/peds.2018-2420ddd","host_type":"journal"}],"fields_of_study":["Food Allergy and Anaphylaxis Research","Transgenic Plants and Applications"],"mesh_terms":[],"keywords":["Medicine","Food allergy","Oral immunotherapy","Quality of life (healthcare)","Oral food challenge","Allergy","Anxiety","Pediatrics","Demographics","Internal medicine","Immunology","Demography","Psychiatry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T06:26:35.673930Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}