{"doi":"10.15407/biph.books.essneur.217","title":"Ca2+ SENSITIZING TROPONIN T MUTATIONS LINKED TO HYPERTROPHIC CARDIOMYOPATHY INCREASE APPARENT CYTOSOLIC Ca2+ BINDING","abstract":"In intact contracting myocytes, the cytosolic free Ca2+ concentration ([Ca2+]free) varies dynamically and is determined by the sarco lemmal and trans-sarcoplasmic reticulum Ca2+ Ⱦ uxes, the binding kinetics to Ca2+ ligands in the cytosol (Ca2+ buˬ ering) and, to a lesser extend, by mitochondrial Ca2+ Ⱦ uxes (Shannon and Bers, 2004; Bers, 2001). Major Ca2+ binding ligands are the myoͽ lament protein Troponin C (TnC; about 50% of fast Ca2+ binding during a typical heart beat), the sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA) and binding sites along the sarcolemmal membrane which remain to be identiͽ ed (Bers, 2001; Fabiato, 1983). Additional Ca2+ is bound by slow Ca2+ buˬ ering sites (Shannon and Bers, 2004). However, these high a ɩ nity Ca2+/Mg2+ binding sites are largely saturated with Mg2+ during diastole (Robertson et al., 1981). Other high-capacity low-a ɩ nity buˬ ers (e.g. ATP, creatine phosphate) in aggregate also signiͽ cantly contribute to Ca2+ buˬ ering (Bers, 2001).","journal":"Akademperiodyka eBooks","year":2020,"id":144868,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":471794,"name":"Sabine Huke","orcid":"0000-0003-1734-7871","position":1,"is_corresponding":false},{"id":614063,"name":"Franz Baudenbacher","orcid":null,"position":2,"is_corresponding":false},{"id":614064,"name":"James D. Potter","orcid":null,"position":3,"is_corresponding":false},{"id":614065,"name":"Bioem C. Knollmann","orcid":null,"position":4,"is_corresponding":false},{"id":614062,"name":"O.V. Hryshchenko","orcid":null,"position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-18T23:17:48.191325Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}