{"doi":"10.15406/ppij.2023.11.00405","title":"Anticonvulsant interactions and anxiolytic effects of Citrus aurantium leaf infusion in the zebrafish","abstract":"Many cultures use Citrus species to address various conditions, notably gastrointestinal dysfunctions, vascular disorders, and central nervous system disturbances. Citrus auratium L preparations have anticonvulsant properties. We examined the interactions of C aurantium (CA) extracts with phenytoin (PHT) or valproic acid (VPA) in pentylenetetrazole-induced seizures in zebrafish. Adult zebrafish were pretreated with the CA extract, the anticonvulsant, or their mixture and challenged with a convulsant dose of pentylenetetrazole. Coadministered C. aurantium 14 mg/mL with 8.0 mM PHT significantly increased seizure latency by 198%. The mixture of C. aurantium 14 mg/ml with VPA 3.0 mM and 6.0 mM showed a significantly higher seizure latency when compared to C. aurantium (107% and 167%, respectively) or VPA (57% and 90%, respectively). Higher doses are toxic. CA extract, 14 mg/mL, potentiates the effects of either PHT or VPA. In contrast, toxicity was more prominent with combinations of C. aurantium 20 mg/ml or 28 mg/ml and VPA. Anxiolytic effects of CA extracts were also observed.","journal":"Pharmacy & Pharmacology International Journal","year":2023,"id":386471,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1155422,"name":"Coral Rosa-Falero","orcid":null,"position":1,"is_corresponding":false},{"id":1155423,"name":"Janelle A Peña-Jiménez","orcid":null,"position":2,"is_corresponding":false},{"id":1155424,"name":"Damaris Joubert-Miranda","orcid":null,"position":3,"is_corresponding":false},{"id":1155425,"name":"Rígel Licier","orcid":null,"position":4,"is_corresponding":false},{"id":419612,"name":"José G. Ortíz","orcid":"0000-0003-1910-2528","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T01:18:00.717763Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}