{"doi":"10.15406/jlprr.2020.07.00239","title":"Cardio-Respiratory tolerability of perfluoropropaneEnhanced MRI of pulmonary ventilation","abstract":"Rationale: Recent advances in perfluoropropane magnetic resonance imaging of the lung have provided the means to assess pulmonary ventilation and gas distribution throughout the pulmonary airways and acini in a non-invasive manner. Objectives: The increased density of the inhaled PFP/O2 gas mixture generates longer wash-in times compared to wash-out while breathing room air and leads to slight increases in airway resistance (Raw) and respiratory effort by the subject during imaging. As a consequence of these gas-related effects, we sought to evaluate the cardio-respiratory tolerability of the PFP/O2 gas mixtures in our sequential breath-hold imaging protocol in normal subjects and subjects with obstructive lung disease. Methods: Tolerability was determined by evaluation of changes in vital signs (Heart Rate, Systolic and Diastolic Blood Pressure, Respiratory Rate and Temperature (otic)) at 3 time points (screening, pre-imaging and post-imaging) Measurements and Main Results: Assessment of vital signs before and after the administration of perfluoropropane gas mixture by matched pair analysis demonstrated statistically different values for Heart rate (Mean Difference =-2.417 bpm), Systolic BP (Mean Difference=6.95 mmHg), Diastolic BP (Mean Difference=3.86 mmHg) and SpO2 (Mean Difference=0.56%) even though these do not represent physiologically significant differences compared to activities of daily living such as climbing a flight of stairs. Conclusions: Our data demonstrate no negative outcomes in using PFP gas to image pulmonary ventilation. The PFP gas mixture is safe, well tolerated, and provides a three dimensional ‘picture’ (representation) of inhaled gas distribution for subject cohorts of normal and obstructive lung disease.","journal":"Journal of Lung Pulmonary & Respiratory Research","year":2020,"id":114751,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":539333,"name":"Richard E. Moon","orcid":"0000-0003-4432-0332","position":1,"is_corresponding":false},{"id":539334,"name":"Neil R. MacIntyre","orcid":"0000-0002-4801-5418","position":2,"is_corresponding":false},{"id":539995,"name":"W. Michael Foster PhD","orcid":null,"position":3,"is_corresponding":false},{"id":539335,"name":"S. Womack","orcid":"0000-0001-8595-4353","position":4,"is_corresponding":false},{"id":539996,"name":"Maureen D. Ainslie MS RTMR","orcid":null,"position":5,"is_corresponding":false},{"id":539336,"name":"H. Page McAdams","orcid":"0000-0002-7044-3320","position":6,"is_corresponding":false},{"id":539997,"name":"Ahmed F. Halaweish","orcid":null,"position":7,"is_corresponding":false},{"id":539998,"name":"Kingshuk Choudury","orcid":null,"position":8,"is_corresponding":false},{"id":539337,"name":"H. Cecil Charles","orcid":"0000-0002-1414-2494","position":9,"is_corresponding":false},{"id":539994,"name":"Joseph Mammarappallil, MD, PhD","orcid":null,"position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-18T23:13:33.226937Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}