{"doi":"10.1534/genetics.107.082032","title":"Independent Effects of <i>cis</i>- and <i>trans</i>-regulatory Variation on Gene Expression in <i>Drosophila melanogaster</i>","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Biochemical interactions between cis-regulatory DNA sequences and trans-regulatory gene products suggest that cis- and trans-acting polymorphisms may interact genetically. Here we present a strategy to test this hypothesis by comparing the relative cis-regulatory activity of two alleles in different genetic backgrounds. Of the eight genes surveyed in this study, five were affected by trans-acting variation that altered total transcript levels, two of which were also affected by differences in cis-regulation. The presence of trans-acting variation had no effect on relative cis-regulatory activity, showing that cis-regulatory polymorphisms can function independently of trans-regulatory variation. The frequency of such independent interactions on a genomic scale is yet to be determined.</jats:p>","journal":"Genetics","year":2008,"id":45423,"datarank":2.7037222535404437,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"self_citation_contribution":0.5709993734655481,"citation_network_contribution":2.132722880074896,"self_endowment_contribution":0.5709993734655481,"citer_contribution":2.132722880074896,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":41,"citers_with_citation_signal":37,"citers_with_endowment":37,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":212157,"name":"Belinda K Haerum","orcid":null,"position":1,"is_corresponding":false},{"id":212158,"name":"Andrew G Clark","orcid":null,"position":2,"is_corresponding":false},{"id":212156,"name":"Patricia J Wittkopp","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18245838","pmcid":"PMC2278090","openalex_id":"https://openalex.org/W2106188986","authors":[],"funders":[{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":2,"fwci":1.8253,"citation_percentile":0.8478422,"influential_citations":5,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":7},{"year":2014,"count":4},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":4},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":4}],"oa_status":"bronze","license":"https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model","oa_locations":[{"url":"https://academic.oup.com/genetics/article-pdf/178/3/1831/42094141/genetics1831.pdf","host_type":"journal"},{"url":"https://academic.oup.com/genetics/article-pdf/178/3/1831/42094141/genetics1831.pdf","host_type":"BRONZE"},{"url":"https://academic.oup.com/genetics/article-pdf/178/3/1831/42094141/genetics1831.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1534/genetics.107.082032","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18245838","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2278090","host_type":"repository"}],"fields_of_study":["Genomics and Chromatin Dynamics","Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","Chromosomal and Genetic Variations","Biology","Medicine","Alleles","Animals","Drosophila melanogaster","Gene Expression Regulation","Hybridization, Genetic","Regulatory Sequences, Nucleic Acid"],"mesh_terms":["Alleles","Animals","Drosophila melanogaster","Gene Expression Regulation","Hybridization, Genetic","Regulatory Sequences, Nucleic Acid"],"keywords":["Biology","Genetics","Trans-acting","Gene","Drosophila melanogaster","Regulatory sequence","Allele","Regulator gene","Genetic variation","Regulation of gene expression","Copy-number variation","Variation (astronomy)","Genome","Mutant"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-03T02:45:52.654819Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}