{"doi":"10.1534/genetics.107.078857","title":"Genetic Analysis of Dauer Formation in\n                    <i>Caenorhabditis briggsae</i>","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Molecular changes that underlie evolutionary changes in behavior and physiology are not well understood. Dauer formation in Caenorhabditis elegans is a temperature-sensitive process controlled through a network of signaling pathways associated with sensory neurons and is potentially an excellent system in which to investigate molecular changes in neuronal function during evolution. To begin to investigate the evolution of dauer formation in the genus Caenorhabditis at the molecular level, we isolated dauer-formation mutations in C. briggsae, a species closely related to the model organism C. elegans. We identified mutations in orthologs of C. elegans genes daf-2 (insulin receptor), daf-3 (Smad), and daf-4 (TGF-β type 2 receptor), as well as genes required for formation of sensory cilia. Phenotypic analyses revealed that functions of these genes are conserved between C. elegans and C. briggsae. Analysis of C. briggsae mutations also revealed a significant difference between the two species in their responses to high temperatures (&amp;gt;26°). C. elegans is strongly induced to form dauers at temperatures above 26°, near the upper limit for growth of C. elegans. In contrast, C. briggsae, which is capable of growth at higher temperatures than C. elegans, lacks this response.</jats:p>","journal":"Genetics","year":2007,"id":589928,"datarank":2.0537242719573943,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":1.48954425460336,"self_endowment_contribution":0.5641800173540344,"citer_contribution":1.48954425460336,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":36,"citers_with_citation_signal":32,"citers_with_endowment":32,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":490372,"name":"Michael Ailion","orcid":"0000-0002-8070-1362","position":1,"is_corresponding":false},{"id":1509411,"name":"Shirley Poon","orcid":null,"position":2,"is_corresponding":false},{"id":1509412,"name":"Hannah K Kim","orcid":null,"position":3,"is_corresponding":false},{"id":1509413,"name":"James H Thomas","orcid":null,"position":4,"is_corresponding":false},{"id":1504244,"name":"Paul W Sternberg","orcid":null,"position":5,"is_corresponding":false},{"id":530068,"name":"Takao Inoue","orcid":"0000-0001-9659-2159","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Genetic Analysis of Dauer Formation in\n                    <i>Caenorhabditis briggsae</i>","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Molecular changes that underlie evolutionary changes in behavior and physiology are not well understood. Dauer formation in Caenorhabditis elegans is a temperature-sensitive process controlled through a network of signaling pathways associated with sensory neurons and is potentially an excellent system in which to investigate molecular changes in neuronal function during evolution. To begin to investigate the evolution of dauer formation in the genus Caenorhabditis at the molecular level, we isolated dauer-formation mutations in C. briggsae, a species closely related to the model organism C. elegans. We identified mutations in orthologs of C. elegans genes daf-2 (insulin receptor), daf-3 (Smad), and daf-4 (TGF-β type 2 receptor), as well as genes required for formation of sensory cilia. Phenotypic analyses revealed that functions of these genes are conserved between C. elegans and C. briggsae. Analysis of C. briggsae mutations also revealed a significant difference between the two species in their responses to high temperatures (&amp;gt;26°). C. elegans is strongly induced to form dauers at temperatures above 26°, near the upper limit for growth of C. elegans. In contrast, C. briggsae, which is capable of growth at higher temperatures than C. elegans, lacks this response.</jats:p>","is_dataset_classified":null,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17660533","pmcid":"PMC2034645","openalex_id":"https://openalex.org/W2111599449","authors":[],"funders":[],"total_grants":0,"fwci":0.9188,"citation_percentile":0.6958012,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":2},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":3},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"bronze","license":"https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model","oa_locations":[{"url":"https://academic.oup.com/genetics/article-pdf/177/2/809/37341712/genetics0809.pdf","host_type":"journal"},{"url":"https://academic.oup.com/genetics/article-pdf/177/2/809/37341712/genetics0809.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/genetics/article-pdf/177/2/809/37341712/genetics0809.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1534/genetics.107.078857","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17660533","host_type":"repository"},{"url":"https://resolver.caltech.edu/CaltechAUTHORS:20190514-084400196","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2034645","host_type":"repository"}],"fields_of_study":["Genetics, Aging, and Longevity in Model Organisms","Circadian rhythm and melatonin","Agriculture Sustainability and Environmental Impact","Adaptation, Physiological","Animals","Caenorhabditis","Caenorhabditis elegans","Caenorhabditis elegans Proteins","Larva","Life Cycle Stages","Mutation","Neurons, Afferent","Receptor, Insulin","Receptors, Transforming Growth Factor beta","Signal Transduction","Smad Proteins","Species Specificity","Temperature"],"mesh_terms":["Adaptation, Physiological","Animals","Caenorhabditis","Larva","Life Cycle Stages","Mutation","Neurons, Afferent","Receptor, Insulin","Species Specificity","Temperature","Signal Transduction","Caenorhabditis elegans","Receptors, Transforming Growth Factor beta","Caenorhabditis elegans Proteins","Smad Proteins"],"keywords":["Caenorhabditis elegans","Biology","Caenorhabditis","Gene","Genetics","Phenotype","Cilium","Mutant","Mutation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T11:17:10.192433Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}