{"doi":"10.15326/jcopdf.2025.0608","title":"Body Mass Index and Bronchodilator Responsiveness in Adults: Analysis of 2 Population-Based Studies in 4 South American Countries","abstract":"Introduction:In South America, the rise in chronic respiratory diseases and weight-related issues due to the ongoing epidemiological transition has prompted research into their interrelationship. Methods:We sought to assess the association between body mass index (BMI) and bronchodilator responsiveness (BDR) among adults in Peru, Chile, Uruguay, and Argentina, using population-based data from two cohort studies.We defined BDR as a 12% and 200 mL increase in either forced expiratory volume in one second (FEV1) or forced vital capacity (FVC) after administration of a short-acting bronchodilator.The analysis also distinguished between FEV-and FVC-specific BDR.We used logistic regression adjusted for confounders to evaluate associations with BMI.Results: Among 7,160 participants (55.2% men, mean age 57.3 years), 23.7% had a BMI <25 kg/m and 35.5% had a BMI 30 kg/m.Overall, 9.5% met the criteria for BDR; with 7.8% showing FEV1specific and 4.9% FVC-specific responses.Compared to a BMI of 20-24.9kg/m, a BMI 30 kg/m was associated with higher odds of FVC-specific BDR (adjusted OR = 1.47, 95% CI 1.08-2.03),whereas a BMI <20 kg/m was associated with FEV-specific BDR among participants with asthma (6.34, 1.16-35.1)and chronic bronchitis (4.71, 1.28-15.9),and with higher odds of any BDR in those with chronic bronchitis (3.90, 1.19-11.93). Conclusion:There was a differential relationship between BMI and types of BDR: higher BMI was associated with FVC-specific responsiveness, whereas lower BMI was linked to FEV-specific BDR in individuals with asthma and chronic bronchitis and to overall BDR in those with chronic bronchitis.","journal":"Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation","year":2025,"id":576766,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9322,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":336848,"name":"Andrés G. Lescano","orcid":"0000-0001-9779-633X","position":1,"is_corresponding":false},{"id":304253,"name":"Robert H. Gilman","orcid":"0000-0002-9037-0712","position":2,"is_corresponding":false},{"id":38941,"name":"J. Jaime Miranda","orcid":"0000-0002-4738-5468","position":3,"is_corresponding":false},{"id":39389,"name":"Antonio Bernabé‐Ortiz","orcid":"0000-0002-6834-1376","position":4,"is_corresponding":false},{"id":39125,"name":"Adolfo Rubinstein","orcid":"0000-0001-6455-2566","position":5,"is_corresponding":false},{"id":956778,"name":"Laura Gutiérrez","orcid":"0000-0002-9423-4320","position":6,"is_corresponding":false},{"id":39461,"name":"Vilma Irazola","orcid":"0000-0002-6100-1862","position":7,"is_corresponding":false},{"id":350029,"name":"Robert A. Wise","orcid":"0000-0002-8353-2349","position":8,"is_corresponding":false},{"id":268905,"name":"William Checkley","orcid":"0000-0003-1106-8812","position":9,"is_corresponding":false},{"id":504857,"name":"Anderson N. Soriano-Moreno","orcid":"0000-0002-5535-811X","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:58:00.620755Z","pmid":"41046133","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}