{"doi":"10.15326/jcopdf.2024.0535","title":"KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency","abstract":"Background: -deficiency is protective in murine models of AAT-deficient emphysema. KF4 anti-CELA1 antibody prevented emphysema in porcine pancreatic elastase (PPE) and cigarette smoke models in wild-type mice. Methods: mice treated with 0.2 units of PPE. Results: mice treated with KF4 1mg/kg weekly, human purified AAT 60mg/kg weekly, and combined KF4 and AAT treatment had less emphysema than mice treated with IgG 1mg/kg weekly. However, the efficacy of KF4, AAT, or KF4 and AAT was similar. Conclusion: While KF4 might be an alternative to AAT replacement, combined KF4 and AAT replacement does not confer additional benefit.","journal":"Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation","year":2024,"id":506706,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9651,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1129421,"name":"Noah J. Smith","orcid":"0009-0000-2711-6255","position":1,"is_corresponding":false},{"id":923418,"name":"Rashika Joshi","orcid":null,"position":2,"is_corresponding":false},{"id":1336681,"name":"Brandon Brooks-Patton","orcid":null,"position":3,"is_corresponding":false},{"id":1336682,"name":"Jenna Dunham","orcid":null,"position":4,"is_corresponding":false},{"id":1336683,"name":"Ansley N. Varisco","orcid":null,"position":5,"is_corresponding":false},{"id":1293321,"name":"Emily Goodman","orcid":"0000-0002-3714-4310","position":6,"is_corresponding":false},{"id":1007639,"name":"Qiang Fan","orcid":"0000-0002-3059-2436","position":7,"is_corresponding":false},{"id":752549,"name":"Basilia Zingarelli","orcid":"0000-0003-0152-700X","position":8,"is_corresponding":false},{"id":526582,"name":"Brian M. Varisco","orcid":"0000-0003-0180-2577","position":9,"is_corresponding":false},{"id":1129782,"name":"Andrew J. Devine","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:10:54.646711Z","pmid":"39636054","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}