{"doi":"10.15326/jcopdf.2023.0468","title":"Higher Plasma Omega-3 Levels are Associated With Improved Exacerbation Risk and Respiratory-Specific Quality of Life in COPD","abstract":"Background: Omega-3 polyunsaturated fatty acids (PUFAs) have been associated with systemic anti-inflammatory responses. Dietary intake of omega-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) has also been associated with lower chronic obstructive pulmonary disease (COPD) morbidity using self-report food frequency questionnaires. Objective: The objective of this study was to investigate the relationship between measured PUFA intake using plasma EPA+DHA levels and COPD morbidity. Methods: Former smokers with moderate-to-severe COPD living in low-income communities were enrolled in a 6-month prospective cohort study. Participants completed standardized questionnaires, spirometry, and plasma samples at 3-month intervals. Total plasma PUFAs were analyzed using gas chromatography/mass spectrometry for DHA and EPA concentrations. Linear or logistic mixed model regression was used to evaluate EPA+DHA's and COPD morbidity's association, accounting for demographics, lung function, pack years, comorbidities, and neighborhood poverty. Results: A total of 133 plasma EPA+DHA samples from 57 participants were available. Participants exhibited average plasma EPA and DHA levels of 14.7±7.3µg/mL and 40.2±17.2µg/mL, respectively, across the 3 clinic visits. Each standard deviation increase in EPA+DHA levels was associated with 2.7 points lower St George's Respiratory Questionnaire score (95% confidence interval [CI] -5.2, -0.2) and lower odds of moderate exacerbation (odds ratio 0.4; 95% CI 0.2, 0.9), but lacked significant association with the COPD Assessment Test score (95% CI -2.4, 0.8), modified Medical Research Council dyspnea scale (95% CI -02, 0.2), or severe exacerbations (95% CI 0.3, 1.4). Conclusion: Plasma EPA+DHA levels are associated with better respiratory-specific quality of life and lower odds of moderate exacerbations in patients with moderate-to-severe COPD. Further research is warranted to investigate the efficacy of an omega-3 dietary intervention in the management of COPD morbidities.","journal":"Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation","year":2024,"id":476682,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":321792,"name":"Han Woo","orcid":null,"position":1,"is_corresponding":false},{"id":916720,"name":"Daniel C. Belz","orcid":"0000-0001-7970-9335","position":2,"is_corresponding":false},{"id":493993,"name":"Ashraf Fawzy","orcid":"0000-0002-6089-366X","position":3,"is_corresponding":false},{"id":1060034,"name":"Wendy Lorizio","orcid":null,"position":4,"is_corresponding":false},{"id":453475,"name":"Michelle N. Eakin","orcid":"0000-0002-8587-8343","position":5,"is_corresponding":false},{"id":319953,"name":"Nirupama Putcha","orcid":"0000-0002-0688-1836","position":6,"is_corresponding":false},{"id":313967,"name":"Meredith C. McCormack","orcid":"0000-0003-1702-3201","position":7,"is_corresponding":false},{"id":313966,"name":"Emily Brigham","orcid":"0000-0002-8449-5420","position":8,"is_corresponding":false},{"id":331186,"name":"Corrine Hanson","orcid":"0000-0002-5118-591X","position":9,"is_corresponding":false},{"id":890832,"name":"Abigail L. Koch","orcid":"0000-0002-6871-2368","position":10,"is_corresponding":false},{"id":250087,"name":"Nadia N. Hansel","orcid":"0000-0002-8740-9751","position":11,"is_corresponding":false},{"id":1314575,"name":"Tyus A. Kemper","orcid":null,"position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:06:29.605760Z","pmid":"38687147","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}