{"doi":"10.15326/jcopdf.2022.0365","title":"Associations Between Muscle Weakness and Clinical Outcomes in Current and Former Smokers","abstract":"Introduction: Smokers with chronic obstructive pulmonary disease (COPD) are at increased risk of muscle weakness. There are limited data describing weakness in smokers with normal spirometry and preserved ratio-impaired spirometry (PRISm), 2 subgroups at risk of respiratory symptom burden and activity limitations. In this study, we evaluated the associations of 2 weakness measures, sit-to-stand (STS) and handgrip strength (HGS), with clinical outcomes in smokers with COPD, normal spirometry, and PRISm. Methods: ) cohort with STS and HGS measurements at their 10-year study visit. Multivariable regression modeling was used to assess associations between weakness measures and the 6-minute walk distance (6MWD) test, the St George's Respiratory Questionnaire (SGRQ), the Short-Form-36 (SF-36), severe exacerbations, and prospective mortality, reported as standardized coefficients (β), odds ratios (ORs), or hazard ratios (HRs). Results: =0.03). Correlations remained after stratification by spirometric subgroups. Compared with males, females had larger magnitude effect sizes between STS and clinical outcomes. Conclusions: STS and HGS are easy to perform weakness measures that provide important information about functional performance, health-related quality of life, severe exacerbations, and survival in smokers, regardless of spirometric subgroup. This iterates the importance of screening current and former smokers for weakness in the outpatient setting.","journal":"Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation","year":2023,"id":360009,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270743,"name":"Mehdi Nouraie","orcid":"0000-0001-7465-0581","position":1,"is_corresponding":false},{"id":227020,"name":"Harry B. Rossiter","orcid":"0000-0002-7884-0726","position":2,"is_corresponding":false},{"id":24993,"name":"Merry‐Lynn McDonald","orcid":"0000-0002-2647-9422","position":3,"is_corresponding":false},{"id":24957,"name":"Dawn L. DeMeo","orcid":"0000-0001-9653-0636","position":4,"is_corresponding":false},{"id":385668,"name":"Stefanie Mason","orcid":"0000-0002-7649-9026","position":5,"is_corresponding":false},{"id":106131,"name":"George R. Washko","orcid":"0000-0002-2712-0569","position":6,"is_corresponding":false},{"id":326544,"name":"Punam K. Saha","orcid":"0000-0003-1576-118X","position":7,"is_corresponding":false},{"id":24990,"name":"Barry J. Make","orcid":"0000-0003-4349-8745","position":8,"is_corresponding":false},{"id":3295,"name":"Richard Casaburi","orcid":"0000-0002-8851-8589","position":9,"is_corresponding":false},{"id":25009,"name":"Elizabeth A. Regan","orcid":"0000-0003-0624-9184","position":10,"is_corresponding":false},{"id":390627,"name":"Jessica Bon","orcid":"0000-0002-4336-3835","position":11,"is_corresponding":false},{"id":352758,"name":"Richard H. Zou","orcid":"0000-0002-0168-5967","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T01:13:57.361401Z","pmid":"36599111","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}