{"doi":"10.15326/jcopdf.2022.0289","title":"Elastin Degradation and Lung Function Deterioration with Remote Secondhand Tobacco Smoke Exposure in Never-smokers","abstract":"Background: Prolonged past exposure to secondhand tobacco smoke (SHS) in never-smokers is associated with abnormal lung function and reduced diffusing capacity suggestive of an associated lung tissue injury and damage. The mechanisms by which past SHS exposure may contribute to lung tissue damage are unknown. Elastin is a major constituent of extracellular matrix in lung parenchyma. Objective: To determine whether past exposure to SHS is associated with ongoing lung tissue damage as indicated by elevated elastin degradation products that are linked to lung function. Methods: We measured the plasma levels of elastin degradation markers (EDM) from 193 never-smoking flight attendants with a history of remote SHS exposure in aircraft cabins and 103 nonsmoking flight attendants or sea-level control participants without such history of cabin SHS exposure and examined those levels versus their lung function with adjustment for covariates. The cabin SHS exposure was estimated based on airline employment history and years of the smoking ban enactment. Results: <0.05). Conclusions: Long after past exposure to SHS, there is ongoing elastin degradation beyond what is expected from the aging process, which likely contributes to lower lung function and a reduced pulmonary capillary bed as seen in chronic obstructive pulmonary disease (COPD).","journal":"Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation","year":2022,"id":279237,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9713,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":420839,"name":"Siyang Zeng","orcid":"0000-0001-9346-301X","position":1,"is_corresponding":false},{"id":643361,"name":"Linnea Rohdin-Bibby","orcid":null,"position":2,"is_corresponding":false},{"id":332144,"name":"Erin L. Van Blarigan","orcid":"0000-0001-5079-3385","position":3,"is_corresponding":false},{"id":833695,"name":"Xingjian Liu","orcid":"0000-0003-4158-3655","position":4,"is_corresponding":false},{"id":833908,"name":"Shuren Ma","orcid":null,"position":5,"is_corresponding":false},{"id":578417,"name":"John P. Kane","orcid":"0000-0001-8049-3850","position":6,"is_corresponding":false},{"id":383154,"name":"Rita F. Redberg","orcid":"0000-0001-6281-0250","position":7,"is_corresponding":false},{"id":833909,"name":"Gerard M. Turino","orcid":null,"position":8,"is_corresponding":false},{"id":578415,"name":"Eveline O. Stock","orcid":"0000-0001-7085-5790","position":9,"is_corresponding":false},{"id":350031,"name":"Mehrdad Arjomandi","orcid":"0000-0002-0116-9217","position":10,"is_corresponding":false},{"id":749125,"name":"Jelena Mustra Rakic","orcid":null,"position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T00:28:51.322666Z","pmid":"35700534","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}