{"doi":"10.15326/jcopdf.2021.0267","title":"Differences of the Nasal Microbiome and Mycobiome by Clinical Characteristics of COPD Patients","abstract":"Rationale: While studies suggest that the lung microbiome may influence risk of chronic obstructive pulmonary disease (COPD) exacerbations, little is known about the relationship between the nasal biome and clinical characteristics of COPD patients. Methods: ], symptom/exacerbation frequency), peripheral eosinophil level (≥150 versus <150 cells/µL) and season of sampling, with the PERMANOVA test on the Bray-Curtis dissimilarities, accounting for within-person correlation of samples. We assessed the relative abundance of microbial features in the nasal community and their associations with clinical characteristics using the Microbiome Multivariable Association with Linear Models (MaAsLin2) package. Results: =0.071). No specific bacterium or fungus differed significantly in relative abundance by clinical characteristics in the multivariate per-feature analysis. Conclusion: The taxonomical composition of the nasal biome is heterogeneous in COPD patients and may be explained in part by clinical characteristics.","journal":"Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation","year":2022,"id":280707,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.942,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":955175,"name":"Chengchen Li","orcid":"0009-0008-3230-4398","position":1,"is_corresponding":false},{"id":453246,"name":"Thomas Kuntz","orcid":"0000-0002-0823-0340","position":2,"is_corresponding":false},{"id":955561,"name":"Lina Nurhussien","orcid":null,"position":3,"is_corresponding":false},{"id":955176,"name":"A. Synn","orcid":"0000-0003-3215-4808","position":4,"is_corresponding":false},{"id":314007,"name":"Wendy Sun","orcid":"0000-0001-7350-964X","position":5,"is_corresponding":false},{"id":955562,"name":"Jiahe Kang","orcid":null,"position":6,"is_corresponding":false},{"id":292464,"name":"Peggy S. Lai","orcid":"0000-0001-9501-8606","position":7,"is_corresponding":false},{"id":614249,"name":"Jeremy E. Wilkinson","orcid":"0000-0002-8024-5600","position":8,"is_corresponding":false},{"id":449931,"name":"Mary B. Rice","orcid":"0000-0003-2538-391X","position":9,"is_corresponding":false},{"id":955560,"name":"Maura Alvarez Baumgartner","orcid":null,"position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T00:29:03.247347Z","pmid":"35487694","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}