{"doi":"10.15326/jcopdf.2021.0263","title":"Characterizing COPD Symptom Variability in the Stable State Utilizing the Evaluating Respiratory Symptoms in COPD Instrument","abstract":"Rationale: It has been suggested that patients with chronic obstructive pulmonary disease (COPD) experience considerable daily respiratory symptom fluctuation. A standardized measure is needed to quantify and understand the implications of day-to-day symptom variability. Objectives: To compare standard deviation with other statistical measures of symptom variability and identify characteristics of individuals with higher symptom variability. Methods: Individuals in the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) Exacerbations sub-study completed an Evaluating Respiratory Symptoms in COPD (E-RS) daily questionnaire. We calculated within-subject standard deviation (WS-SD) for each patient at week 0 and correlated this with measurements obtained 4 weeks later using Pearson's r and Bland Altman plots. Median WS-SD value dichotomized participants into higher versus lower variability groups. Association between WS-SD and exacerbation risk during 4 follow-up weeks was explored. Measurements and Main Results: =.04) than lower variability participants. Exploratory analyses found no relationship between symptom variability and health care resource utilization-defined exacerbations. Conclusions: WS-SD of the E-RS can be used as a measure of symptom variability in studies of patients with COPD. Patients with higher variability have worse health-related quality of life. WS-SD should be further validated as a measure to understand the implications of symptom variability.","journal":"Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation","year":2022,"id":284774,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":962534,"name":"Kayley Ancy","orcid":"0009-0005-3059-3083","position":1,"is_corresponding":false},{"id":361295,"name":"Clara Oromendia","orcid":"0000-0001-9231-3351","position":2,"is_corresponding":false},{"id":431329,"name":"Katherine L. Hoffman","orcid":null,"position":3,"is_corresponding":false},{"id":520998,"name":"Imaani Easthausen","orcid":"0000-0002-4673-6772","position":4,"is_corresponding":false},{"id":837685,"name":"Nancy Kline Leidy","orcid":null,"position":5,"is_corresponding":false},{"id":250088,"name":"MeiLan K. Han","orcid":"0000-0002-9095-4419","position":6,"is_corresponding":false},{"id":24947,"name":"Russell P. Bowler","orcid":"0000-0003-4651-363X","position":7,"is_corresponding":false},{"id":250080,"name":"Stephanie A. Christenson","orcid":"0000-0003-1550-2815","position":8,"is_corresponding":false},{"id":250083,"name":"David Couper","orcid":"0000-0002-4313-9235","position":9,"is_corresponding":false},{"id":250084,"name":"Gerard J. Criner","orcid":"0000-0003-1267-3483","position":10,"is_corresponding":false},{"id":24955,"name":"Jeffrey L. Curtis","orcid":"0000-0001-5191-4847","position":11,"is_corresponding":false},{"id":250085,"name":"Mark T. Dransfield","orcid":"0000-0002-9207-1820","position":12,"is_corresponding":false},{"id":250087,"name":"Nadia N. Hansel","orcid":"0000-0002-8740-9751","position":13,"is_corresponding":false},{"id":641977,"name":"Anand Iyer","orcid":"0000-0001-7700-0728","position":14,"is_corresponding":false},{"id":250094,"name":"Robert Paine","orcid":"0000-0002-4511-4437","position":15,"is_corresponding":false},{"id":250095,"name":"Stephen P. Peters","orcid":"0000-0003-4176-7999","position":16,"is_corresponding":false},{"id":825591,"name":"Jadwiga A. Wedzicha","orcid":"0000-0001-9642-1261","position":17,"is_corresponding":false},{"id":250097,"name":"Prescott G. Woodruff","orcid":"0000-0003-3176-0603","position":18,"is_corresponding":false},{"id":259331,"name":"Karla V. Ballman","orcid":"0000-0002-4492-0357","position":19,"is_corresponding":false},{"id":33125,"name":"Fernando J. Martínez","orcid":"0000-0002-2412-3182","position":20,"is_corresponding":false},{"id":634569,"name":"Jamuna K. 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