{"doi":"10.1532/ijh97.07058","title":"Distinct Clones are Associated with the Development of Transient Myeloproliferative Disorder and Acute Megakaryocytic Leukemia in a Patient with Down Syndrome","abstract":null,"journal":"International Journal of Hematology","year":2007,"id":624172,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1613390,"name":"Sayaka Watanabe","orcid":null,"position":1,"is_corresponding":false},{"id":1613391,"name":"Keiko Nomura","orcid":null,"position":2,"is_corresponding":false},{"id":41790,"name":"Gang Xu","orcid":"0000-0003-2329-9458","position":3,"is_corresponding":false},{"id":757380,"name":"Etsuro Ito","orcid":"0000-0002-0168-2475","position":4,"is_corresponding":false},{"id":1550398,"name":"Toshio Miyawaki","orcid":null,"position":5,"is_corresponding":false},{"id":650027,"name":"Hirokazu Kanegane","orcid":"0000-0002-8696-9378","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Distinct Clones are Associated with the Development of Transient Myeloproliferative Disorder and Acute Megakaryocytic Leukemia in a Patient with Down Syndrome","abstract":"Children with Down syndrome (DS) have an approximately 20-fold higher incidence of leukemia than unaffected children, and most leukemia cases with DS present as acute megakaryocytic leukemia (AMKL). At least 10% of neonates with DS develop transient myeloproliferative disorder (TMD), and 20% to 30% of patients with TMD develop AMKL. Mutations in the GATA1 gene are identified not only in AMKL patients but also in TMD patients; however, sequential analysis of GATA1 is not often performed in the same patients. We describe a child with DS who developed TMD followed by AMKL and have identified different mutations in the GATA1 gene during the course of TMD and AMKL. Distinct clones were associated with the development of TMD and AMKL in this patient.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17988992","pmcid":null,"openalex_id":"https://openalex.org/W2021329747","authors":[],"funders":[],"total_grants":0,"fwci":0.3011,"citation_percentile":0.5719346,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2015,"count":1}],"oa_status":"closed","license":"https://www.springer.com/tdm","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1532/IJH97.07058.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1532/IJH97.07058/fulltext.html","host_type":"publisher"},{"url":"http://dx.doi.org/10.1532/ijh97.07058","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17988992","host_type":"repository"}],"fields_of_study":["Acute Myeloid Leukemia Research","Hemoglobinopathies and Related Disorders","Acute Lymphoblastic Leukemia research"],"mesh_terms":["Down Syndrome","Humans","Infant","Leukemia, Megakaryoblastic, Acute","Male","Myeloproliferative Disorders"],"keywords":["GATA1","Down syndrome","Acute megakaryoblastic leukemia","Leukemia","Medicine","Acute leukemia","Hematology","Incidence (geometry)","Pediatrics","Internal medicine","Anemia","Erythropoiesis","Psychiatry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T02:58:08.299341Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}