{"doi":"10.1530/joe-16-0199","title":"Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse","abstract":"<jats:p>\n                    The brown adipose tissue (BAT) mediates adaptive changes in metabolic rate by responding to the sympathetic nervous system through β-adrenergic receptors (AR). Here, we wished to define the role played by the ARβ\n                    <jats:sub>3</jats:sub>\n                    isoform in this process. This study focused on the ARβ\n                    <jats:sub>3</jats:sub>\n                    knockout mice (ARβ\n                    <jats:sub>3</jats:sub>\n                    KO), including responsiveness to cold exposure, diet-induced obesity, intolerance to glucose, dyslipidaemia and lipolysis in white adipose tissue (WAT). ARβ\n                    <jats:sub>3</jats:sub>\n                    KO mice defend core temperature during cold exposure (4°C for 5 h), with faster BAT thermal response to norepinephrine (NE) infusion when compared with wild-type (WT) mice. Despite normal BAT thermogenesis, ARβ\n                    <jats:sub>3</jats:sub>\n                    KO mice kept on a high-fat diet (HFD; 40% fat) for 8 weeks exhibited greater susceptibility to diet-induced obesity, markedly increased epididymal adipocyte area with clear signs of inflammation. The HFD-induced glucose intolerance was similar in both groups but serum hypertriglyceridemia and hypercholesterolemia were less intense in ARβ\n                    <jats:sub>3</jats:sub>\n                    KO animals when compared with WT controls. Isoproterenol-induced lipolysis in isolated white adipocytes as assessed by glycerol release was significantly impaired in ARβ\n                    <jats:sub>3</jats:sub>\n                    KO animals despite normal expression of key proteins involved in lipid metabolism. In conclusion, ARβ\n                    <jats:sub>3</jats:sub>\n                    inactivation does not affect BAT thermogenesis but increases susceptibility to diet-induced obesity by dampening WAT lipolytic response to adrenergic stimulation.\n                  </jats:p>","journal":"Journal of Endocrinology","year":2016,"id":596915,"datarank":0.5333022092234121,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.0,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1528939,"name":"Bruna P P do Nascimento","orcid":null,"position":1,"is_corresponding":false},{"id":1528940,"name":"Cynthia R Muller","orcid":null,"position":2,"is_corresponding":false},{"id":1528941,"name":"Anna Laura V Américo","orcid":null,"position":3,"is_corresponding":false},{"id":1528942,"name":"Talita S Higa","orcid":null,"position":4,"is_corresponding":false},{"id":1528943,"name":"Fabiana S Evangelista","orcid":null,"position":5,"is_corresponding":false},{"id":1528944,"name":"Carmen L Lancellotti","orcid":null,"position":6,"is_corresponding":false},{"id":1528945,"name":"Felipe dos Santos Henriques","orcid":null,"position":7,"is_corresponding":false},{"id":1528946,"name":"Miguel Luiz Batista","orcid":null,"position":8,"is_corresponding":false},{"id":1528947,"name":"Antonio C Bianco","orcid":null,"position":9,"is_corresponding":false},{"id":1528948,"name":"Miriam O Ribeiro","orcid":null,"position":10,"is_corresponding":false},{"id":1528938,"name":"Nailliw Z Preite","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse","abstract":"<jats:p>\n                    The brown adipose tissue (BAT) mediates adaptive changes in metabolic rate by responding to the sympathetic nervous system through β-adrenergic receptors (AR). Here, we wished to define the role played by the ARβ\n                    <jats:sub>3</jats:sub>\n                    isoform in this process. This study focused on the ARβ\n                    <jats:sub>3</jats:sub>\n                    knockout mice (ARβ\n                    <jats:sub>3</jats:sub>\n                    KO), including responsiveness to cold exposure, diet-induced obesity, intolerance to glucose, dyslipidaemia and lipolysis in white adipose tissue (WAT). ARβ\n                    <jats:sub>3</jats:sub>\n                    KO mice defend core temperature during cold exposure (4°C for 5 h), with faster BAT thermal response to norepinephrine (NE) infusion when compared with wild-type (WT) mice. Despite normal BAT thermogenesis, ARβ\n                    <jats:sub>3</jats:sub>\n                    KO mice kept on a high-fat diet (HFD; 40% fat) for 8 weeks exhibited greater susceptibility to diet-induced obesity, markedly increased epididymal adipocyte area with clear signs of inflammation. The HFD-induced glucose intolerance was similar in both groups but serum hypertriglyceridemia and hypercholesterolemia were less intense in ARβ\n                    <jats:sub>3</jats:sub>\n                    KO animals when compared with WT controls. Isoproterenol-induced lipolysis in isolated white adipocytes as assessed by glycerol release was significantly impaired in ARβ\n                    <jats:sub>3</jats:sub>\n                    KO animals despite normal expression of key proteins involved in lipid metabolism. In conclusion, ARβ\n                    <jats:sub>3</jats:sub>\n                    inactivation does not affect BAT thermogenesis but increases susceptibility to diet-induced obesity by dampening WAT lipolytic response to adrenergic stimulation.\n                  </jats:p>","is_dataset_classified":null,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27672060","pmcid":"PMC5609459","openalex_id":"https://openalex.org/W2527047102","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK065055","title":null}],"total_grants":1,"fwci":2.057,"citation_percentile":0.86696754,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":4},{"year":2019,"count":5},{"year":2020,"count":6},{"year":2021,"count":3},{"year":2022,"count":6},{"year":2023,"count":3},{"year":2024,"count":4},{"year":2025,"count":1}],"oa_status":"bronze","license":"other-oa","oa_locations":[{"url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/231/3/259.pdf","host_type":"journal"},{"url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/231/3/259.pdf","host_type":"publisher"},{"url":"https://joe.bioscientifica.com/view/journals/joe/231/3/259.xml","host_type":"publisher"},{"url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/231/3/259.xml","host_type":"publisher"},{"url":"https://doi.org/10.1530/joe-16-0199","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27672060","host_type":"repository"},{"url":"http://dx.doi.org/10.1530/JOE-16-0199","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5609459","host_type":"repository"},{"url":"https://repositorio.unifesp.br/handle/11600/56682","host_type":"repository"}],"fields_of_study":["Adipose Tissue and Metabolism","Adipokines, Inflammation, and Metabolic Diseases","Exercise and Physiological Responses"],"mesh_terms":["Animals","Adipose Tissue, Brown","Cold Temperature","Lipolysis","Male","Norepinephrine","Obesity","Mice, Knockout","Receptors, Adrenergic, beta-3","Thermogenesis","Adiposity","Lipid Metabolism","Mice","Adipose Tissue, White","Diet, High-Fat"],"keywords":["Endocrinology","Internal medicine","Thermogenesis","Lipolysis","Brown adipose tissue","White adipose tissue","Adipose tissue","Stimulation","Adrenergic receptor","Adrenergic","Thermogenin","Adipocyte","Receptor","Biology","Beta-3 adrenergic receptor","Chemistry","Medicine","Obesity","Adaptive thermogenesis","Β3 Adrenergic Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T11:42:00.495566Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}