{"doi":"10.1530/jme-14-0290","title":"Role of transcription factors in the transdifferentiation of pancreatic islet cells","abstract":"<jats:p>The α and β cells act in concert to maintain blood glucose. The α cells release glucagon in response to low levels of glucose to stimulate glycogenolysis in the liver. In contrast, β cells release insulin in response to elevated levels of glucose to stimulate peripheral glucose disposal. Despite these opposing roles in glucose homeostasis, α and β cells are derived from a common progenitor and share many proteins important for glucose sensing and hormone secretion. Results from recent work have underlined these similarities between the two cell types by revealing that β-to-α as well as α-to-β transdifferentiation can take place under certain experimental circumstances. These exciting findings highlight unexpected plasticity of adult islets and offer hope of novel therapeutic paths to replenish β cells in diabetes. In this review, we focus on the transcription factor networks that establish and maintain pancreatic endocrine cell identity and how they may be perturbed to facilitate transdifferentiation.</jats:p>","journal":"Journal of Molecular Endocrinology","year":2015,"id":637597,"datarank":0.7254422860427218,"base_score":4.836281906951478,"endowment":4.836281906951478,"self_citation_contribution":0.7254422860427218,"citation_network_contribution":0.0,"self_endowment_contribution":0.7254422860427218,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":125,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1655661,"name":"Mark O Huising","orcid":null,"position":1,"is_corresponding":false},{"id":706129,"name":"Talitha van der Meulen","orcid":"0000-0002-2150-9258","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Role of transcription factors in the transdifferentiation of pancreatic islet cells","abstract":"<jats:p>The α and β cells act in concert to maintain blood glucose. The α cells release glucagon in response to low levels of glucose to stimulate glycogenolysis in the liver. In contrast, β cells release insulin in response to elevated levels of glucose to stimulate peripheral glucose disposal. Despite these opposing roles in glucose homeostasis, α and β cells are derived from a common progenitor and share many proteins important for glucose sensing and hormone secretion. Results from recent work have underlined these similarities between the two cell types by revealing that β-to-α as well as α-to-β transdifferentiation can take place under certain experimental circumstances. These exciting findings highlight unexpected plasticity of adult islets and offer hope of novel therapeutic paths to replenish β cells in diabetes. In this review, we focus on the transcription factor networks that establish and maintain pancreatic endocrine cell identity and how they may be perturbed to facilitate transdifferentiation.</jats:p>","is_dataset_classified":null,"base_score":4.836281906951478,"endowment":4.836281906951478,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25791577","pmcid":"PMC4373662","openalex_id":"https://openalex.org/W2130813390","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"P01-DK026741","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P01 DK026741","title":null}],"total_grants":2,"fwci":8.5302,"citation_percentile":0.98336593,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":3},{"year":2016,"count":8},{"year":2017,"count":6},{"year":2018,"count":13},{"year":2019,"count":16},{"year":2020,"count":10},{"year":2021,"count":16},{"year":2022,"count":18},{"year":2023,"count":12},{"year":2024,"count":13},{"year":2025,"count":6},{"year":2026,"count":3}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://jme.bioscientifica.com/downloadpdf/journals/jme/54/2/R103.pdf","host_type":"journal"},{"url":"https://jme.bioscientifica.com/downloadpdf/journals/jme/54/2/R103.pdf","host_type":"publisher"},{"url":"https://jme.bioscientifica.com/view/journals/jme/54/2/R103.xml","host_type":"publisher"},{"url":"https://jme.bioscientifica.com/downloadpdf/journals/jme/54/2/R103.xml","host_type":"publisher"},{"url":"https://doi.org/10.1530/jme-14-0290","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25791577","host_type":"repository"},{"url":"https://escholarship.org/uc/item/1qm942s9","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4373662","host_type":"repository"},{"url":"http://www.escholarship.org/uc/item/1qm942s9","host_type":"repository"}],"fields_of_study":["Pancreatic function and diabetes","Diabetes and associated disorders","Diabetes Management and Research"],"mesh_terms":["Homeobox Protein Nkx-2.2","Animals","Humans","Models, Biological","Nuclear Proteins","Transcription Factors","Homeodomain Proteins","Glucagon-Secreting Cells","Insulin-Secreting Cells","Gene Regulatory Networks","Cell Transdifferentiation"],"keywords":["Transdifferentiation","Glucose homeostasis","PAX4","Transcription factor","Enteroendocrine cell","Biology","Glucagon","Progenitor cell","Cell biology","Pancreatic islets","Endocrinology","Islet","Internal medicine","Insulin","Hormone","Stem cell","Endocrine system","Medicine","Insulin resistance","Biochemistry","Gene","Homeobox","Dedifferentiation","Diabetes","β cell","Arx","Foxo1","Pdx1","Nkx2-2","Α Cell"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T19:13:03.430703Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}