{"doi":"10.1530/eje-15-0118","title":"MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management","abstract":"<jats:p>Osteoporosis is a skeletal disorder characterized by decreased mass and compromised bone strength predisposing to an increased risk of fractures. Although idiopathic osteoporosis is the most common form of osteoporosis, secondary factors may contribute to the bone loss and increased fracture risk in patients presenting with fragility fractures or osteoporosis. Several medical conditions and medications significantly increase the risk for bone loss and skeletal fragility. This review focuses on some of the common causes of osteoporosis, addressing the underlying mechanisms, diagnostic approach and treatment of low bone mass in the presence of these conditions.</jats:p>","journal":"European Journal of Endocrinology","year":2015,"id":591967,"datarank":9.055995764469882,"base_score":5.83773044716594,"endowment":5.83773044716594,"self_citation_contribution":0.8756595670748912,"citation_network_contribution":8.180336197394992,"self_endowment_contribution":0.8756595670748912,"citer_contribution":8.180336197394992,"corpus_percentile":null,"corpus_rank":null,"citation_count":342,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":588026,"name":"Ernesto Canalis","orcid":"0000-0002-9154-952X","position":1,"is_corresponding":false},{"id":1217423,"name":"Faryal Mirza","orcid":"0000-0002-7331-097X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Management of endocrine disease: Secondary osteoporosis: pathophysiology and management.","abstract":"Osteoporosis is a skeletal disorder characterized by decreased mass and compromised bone strength predisposing to an increased risk of fractures. Although idiopathic osteoporosis is the most common form of osteoporosis, secondary factors may contribute to the bone loss and increased fracture risk in patients presenting with fragility fractures or osteoporosis. Several medical conditions and medications significantly increase the risk for bone loss and skeletal fragility. This review focuses on some of the common causes of osteoporosis, addressing the underlying mechanisms, diagnostic approach and treatment of low bone mass in the presence of these conditions.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25971649","pmcid":"PMC4534332","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"DK045227","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"AR063049","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK045227","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"R01 AR063049","title":null}],"total_grants":4,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4534332","host_type":"repository"}],"fields_of_study":[],"mesh_terms":["Humans","Multiple Myeloma","Acromegaly","Osteoporosis","Inflammatory Bowel Diseases","Celiac Disease","Diabetes Mellitus, Type 1","Diabetes Mellitus, Type 2","Hypogonadism","Hyperthyroidism","Autoimmune Diseases","Human Growth Hormone","Thyroxine","Antineoplastic Agents, Hormonal","Aromatase Inhibitors","Glucocorticoids","Hyperparathyroidism, Primary","Gonadotropin-Releasing Hormone","Medroxyprogesterone Acetate","Chronic Kidney Disease-Mineral and Bone Disorder"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T11:36:00.509195Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}