{"doi":"10.1530/acta.0.1270441","title":"Re-expression of thyroxine-binding globulin in post-weaning rats during protein or energy malnutrition","abstract":"<jats:p>Thyroxine-binding globulin, the highest affinity thyroid hormone binder of rat serum, was studied during 28 days of dietary protein restriction (6% protein vs 18% protein in isocaloric control diet) or energy restriction (60% intake of control diet). Studies were performed on male rats aged four weeks at the beginning of experiments: the animals had reached the ontogenic stage when the thyroxine-binding globulin had declined, after its high postnatal surge, to undetectable levels. Short-term administration (seven days) of one or the other restricted diet similarly induced resynthesis of the protein. Its serum concentrations reached 26–46% of those measured in eight-day pups (peak of the neonatal surge) and its liver mRNAs showed corresponding enhanced signals. Serum T<jats:sub>4</jats:sub> binding activities were increased, although concomitantly transthyretin, second specific T<jats:sub>4</jats:sub> carrier of the rat serum, decreased markedly (65–75% of controls) in response to the dietary restrictions. Longer-term diet administration (14 or 28 days) resulted in the further increase of the thyroxine-binding globulin in the protein-restricted rats, in contrast to its decline and eventual disappearance in the energy-restricted animals. Protein restriction was associated with increased total and free T<jats:sub>3</jats:sub> serum concentrations, in contrast to energy restriction which little affected these parameters. These studies reveal rat thyroxine-binding globulin as a positive (increasing), highly sensitive reactant of malnutrition, able to discriminate between energy deficiency and composition dysequilibrium of diets. They suggest that up-regulation of its synthesis in the two dietary models involves differential mechanisms.</jats:p>","journal":"Acta Endocrinologica","year":1992,"id":684610,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1788530,"name":"Lia Savu","orcid":null,"position":1,"is_corresponding":false},{"id":1629688,"name":"Roger Vranckx","orcid":null,"position":2,"is_corresponding":false},{"id":1788531,"name":"Fanny Bleiberg-Daniel","orcid":null,"position":3,"is_corresponding":false},{"id":1788532,"name":"Béatrice Le Moullac","orcid":null,"position":4,"is_corresponding":false},{"id":1788533,"name":"Patricia Gouache","orcid":null,"position":5,"is_corresponding":false},{"id":1788534,"name":"Emmanuel A Nunez","orcid":null,"position":6,"is_corresponding":false},{"id":1788529,"name":"Marielle Rouaze-Romet","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Re-expression of thyroxine-binding globulin in post-weaning rats during protein or energy malnutrition","abstract":"<jats:p>Thyroxine-binding globulin, the highest affinity thyroid hormone binder of rat serum, was studied during 28 days of dietary protein restriction (6% protein vs 18% protein in isocaloric control diet) or energy restriction (60% intake of control diet). Studies were performed on male rats aged four weeks at the beginning of experiments: the animals had reached the ontogenic stage when the thyroxine-binding globulin had declined, after its high postnatal surge, to undetectable levels. Short-term administration (seven days) of one or the other restricted diet similarly induced resynthesis of the protein. Its serum concentrations reached 26–46% of those measured in eight-day pups (peak of the neonatal surge) and its liver mRNAs showed corresponding enhanced signals. Serum T<jats:sub>4</jats:sub> binding activities were increased, although concomitantly transthyretin, second specific T<jats:sub>4</jats:sub> carrier of the rat serum, decreased markedly (65–75% of controls) in response to the dietary restrictions. Longer-term diet administration (14 or 28 days) resulted in the further increase of the thyroxine-binding globulin in the protein-restricted rats, in contrast to its decline and eventual disappearance in the energy-restricted animals. Protein restriction was associated with increased total and free T<jats:sub>3</jats:sub> serum concentrations, in contrast to energy restriction which little affected these parameters. These studies reveal rat thyroxine-binding globulin as a positive (increasing), highly sensitive reactant of malnutrition, able to discriminate between energy deficiency and composition dysequilibrium of diets. They suggest that up-regulation of its synthesis in the two dietary models involves differential mechanisms.</jats:p>","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1471456","pmcid":null,"openalex_id":"https://openalex.org/W2136211540","authors":[],"funders":[],"total_grants":0,"fwci":0.2153,"citation_percentile":0.42475728,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2019,"count":2},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://eje.bioscientifica.com/view/journals/eje/127/5/acta_127_5_011.xml","host_type":"publisher"},{"url":"https://doi.org/10.1530/acta.0.1270441","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1471456","host_type":"repository"}],"fields_of_study":["Regulation of Appetite and Obesity","Thyroid Disorders and Treatments","Metabolism, Diabetes, and Cancer"],"mesh_terms":["Animals","Energy Intake","Liver","Male","Nutrition Disorders","Osmolar Concentration","Prealbumin","Protein Deficiency","RNA, Messenger","Thyroid Hormones","Thyroxine-Binding Proteins","Weaning","Rats, Wistar","Rats"],"keywords":["Internal medicine","Endocrinology","Transthyretin","Thyroxine-binding globulin","Weaning","Globulin","Biology","Hormone","Thyroid","Binding protein","Thyroxine-binding proteins","Triiodothyronine","Medicine","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T14:34:38.346868Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}