{"doi":"10.1530/acta.0.1210705","title":"Decreased glucagon binding and glucagon-stimulated lipolysis in adipocytes from streptozotocin-diabetic rats","abstract":"<jats:title>Abstract.</jats:title>\n<jats:p>Adipocytes from streptozotocin-diabetic rats showed a markedly reduced lipolytic response to glucagon concomitant with a 90% or greater decrease in the number of glucagon receptors per cell. In contrast, β-adrenergic receptors assessed by [<jats:sup>3</jats:sup>H]dihydroalprenolol binding and lipolysis stimulated by isoproterenol, dibutyryl 3′5′-cyclic AMP and 3-isobutyl-1-methylxanthine were reduced by only 10–25% in diabetic rats compared with controls. Furthermore, quantitative analysis of the relationship between the amount of cell-bound glucagon and the hormone-stimulated lipolysis revealed that the function of the remaining 10% of glucagon receptors remained intact in cells from diabetic animals. These findings suggest that the lipolytic cascades, including β-adrenergic receptors, in adipocytes are not greatly impaired by diabetes, and therefore, the unresponsiveness of these cells to glucagon is mostly due to a marked reduction in the number of glucagon receptors, probably as a result of a down-regulation by postprandial hyperglucagonemia.</jats:p>","journal":"Acta Endocrinologica","year":1989,"id":40739,"datarank":0.3048443252340952,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.09690017106611161,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.09690017106611161,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":197400,"name":"Minoru Irie","orcid":null,"position":1,"is_corresponding":false},{"id":197401,"name":"Hiroshi Kajinuma","orcid":null,"position":2,"is_corresponding":false},{"id":197402,"name":"Kazuo Suzuki","orcid":null,"position":3,"is_corresponding":false},{"id":197399,"name":"Nobuyuki Sato","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"2555994","pmcid":null,"openalex_id":"https://openalex.org/W2145722810","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.15120081,"influential_citations":0,"citation_trend":[{"year":2012,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://eje.bioscientifica.com/view/journals/eje/121/5/acta_121_5_017.xml","host_type":"publisher"},{"url":"https://doi.org/10.1530/acta.0.1210705","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/2555994","host_type":"repository"}],"fields_of_study":["Diabetes Treatment and Management","Metabolism, Diabetes, and Cancer","Pancreatic function and diabetes","Medicine","Biology"],"mesh_terms":["Adipose Tissue","Animals","Diabetes Mellitus, Experimental","Dihydroalprenolol","Glucagon","Isoproterenol","Lipolysis","Male","Rats, Inbred Strains","Receptors, Gastrointestinal Hormone","Receptors, Glucagon","Rats"],"keywords":["Glucagon","Internal medicine","Endocrinology","Lipolysis","Hyperglucagonemia","Dihydroalprenolol","Receptor","Streptozotocin","Postprandial","Adrenergic receptor","Chemistry","Diabetes mellitus","Insulin","Biology","Medicine","Adipose tissue","Antagonist"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T14:28:43.188289Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}